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Review
. 2017 Jul;18(7):435-450.
doi: 10.1038/nrn.2017.62. Epub 2017 Jun 8.

Non-motor features of Parkinson disease

Anthony H V Schapira  1 , K Ray Chaudhuri  2 , Peter Jenner  3
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Free article
Review

Non-motor features of Parkinson disease

Anthony H V Schapira et al. Nat Rev Neurosci. 2017 Jul.
Free article

Erratum in

  • Non-motor features of Parkinson disease.
    Schapira AHV, Chaudhuri KR, Jenner P. Schapira AHV, et al. Nat Rev Neurosci. 2017 Aug;18(8):509. doi: 10.1038/nrn.2017.91. Epub 2017 Jul 13. Nat Rev Neurosci. 2017. PMID: 28720825

Abstract

Many of the motor symptoms of Parkinson disease (PD) can be preceded, sometimes for several years, by non-motor symptoms that include hyposmia, sleep disorders, depression and constipation. These non-motor features appear across the spectrum of patients with PD, including individuals with genetic causes of PD. The neuroanatomical and neuropharmacological bases of non-motor abnormalities in PD remain largely undefined. Here, we discuss recent advances that have helped to establish the presence, severity and effect on the quality of life of non-motor symptoms in PD, and the neuroanatomical and neuropharmacological mechanisms involved. We also discuss the potential for the non-motor features to define a prodrome that may enable the early diagnosis of PD.

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References

    1. J Affect Disord. 2011 Jul;132(1-2):82-8 - PubMed
    1. Neurogastroenterol Motil. 2009 Feb;21(2):215-22 - PubMed
    1. Ann Neurol. 2013 Sep;74(3):337-47 - PubMed
    1. Br J Pharmacol. 2003 Aug;139(8):1425-32 - PubMed
    1. Arch Neurol. 2010 Jun;67(6):670-6 - PubMed

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