Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jul 11;89(2):138-143.
doi: 10.1212/WNL.0000000000004078. Epub 2017 Jun 7.

Baseline motor findings and Parkinson disease prognostic subtypes

Ali H Rajput  1 , Michele L Rajput  2 , Leslie W Ferguson  2 , Alex Rajput  2
Affiliations

Baseline motor findings and Parkinson disease prognostic subtypes

Ali H Rajput et al. Neurology. .

Abstract

Objective: To identify the significance of baseline motor features to the lifelong prognostic motor subtypes in a Parkinson disease (PD) cohort.

Methods: In a previous study of 166 PD cases, we observed different prognosis in tremor-dominant, akinetic-rigid, and mixed subtypes. This study includes the same cases, but we excluded 10 cases with symptoms of ≥15 years duration at baseline. Relative severity of tremor, bradykinesia/akinesia, and rigidity at baseline were evaluated as predictors of the motor subtypes, which are known to have different prognosis.

Results: The most common motor subtype was mixed, followed by akinetic-rigid and then the tremor-dominant. Seventy cases were not receiving antiparkinsonian drugs at baseline. The prognostic subtypes could be predicted at baseline in 85% of all and in 91% of the treatment-naive cases. Sensitivity, specificity, and positive predictive values were strong for the mixed and the akinetic-rigid but weak for the tremor-dominant subtype.

Conclusions: Our data show that motor profile at baseline can predict prognosis in most PD cases. These findings can be incorporated into clinical practice.

PubMed Disclaimer

Figures

Figure
Figure. Flow diagram of Movement Disorders Clinic Saskatchewan
H&Y = Hoehn & Yahr scale; MSE = Mini-Mental State Examination; UPDRS = Unified Parkinson’s Disease Rating Scale.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Jellinger K. The pathology of parkinsonism. In: Marsden CD, Fahn S, eds. Movement Disorders 2. London: Butterworths; 1987:124–165.
    1. Rajput AH, Rozdilsky B, Rajput A. Accuracy of clinical diagnosis in parkinsonism: a prospective study. Can J Neurol Sci 1991;18:275–278. - PubMed
    1. Hoehn MM, Yahr MD. Parkinsonism: onset, progression, and mortality. Neurology 1967;17:427–442. - PubMed
    1. Pagano G, Ferrara N, Brooks DJ, et al. . Age at onset and Parkinson disease phenotype. Neurology 2016;86:1400–1407. - PMC - PubMed
    1. Postuma RB, Berg D, Stern M, et al. . MDS clinical diagnostic criteria for Parkinson's disease. Mov Disord 2015;30:1591–1599. - PubMed

MeSH terms