The viral and cellular forms of the Abelson (abl) oncogene
- PMID: 2852893
- DOI: 10.1016/s0065-3527(08)60708-3
The viral and cellular forms of the Abelson (abl) oncogene
Abstract
The precision of molecular biology has allowed a better definition of the components of the Abelson system. We know the gene structures and gene products for the cellular and viral forms of this family of related tyrosine kinases. However, many basic issues first identified in the early biological observations of Abelson, Rabstein, and others remain unanswered. The precise pathway for transformation in biochemical terms remains unknown for Ab-MLV and all of its relatives. Relatively little can be said to explain the preferential growth stimulation for certain hematopoietic cell types by the viral and other altered forms of the oncogene, and no clear insights into the function of the normal cellular forms of the abl oncogene are available. Future progress will certainly depend on the intensive efforts by many workers in the broader field of cellular growth control mechanisms.
Similar articles
-
Abelson virus: current status of a viral oncogene.Proc Soc Exp Biol Med. 1988 Jul;188(3):235-42. doi: 10.3181/00379727-188-42732. Proc Soc Exp Biol Med. 1988. PMID: 2839844 Review. No abstract available.
-
The Abelson murine leukemia virus oncogene.Proc Soc Exp Biol Med. 1985 Sep;179(4):403-12. doi: 10.3181/00379727-179-42115. Proc Soc Exp Biol Med. 1985. PMID: 2991935 Review. No abstract available.
-
Structure and function of the Abelson murine leukemia virus transforming gene.Prog Clin Biol Res. 1983;119:57-63. Prog Clin Biol Res. 1983. PMID: 6306691
-
Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity.Proc Natl Acad Sci U S A. 1983 Jun;80(12):3623-7. doi: 10.1073/pnas.80.12.3623. Proc Natl Acad Sci U S A. 1983. PMID: 6304726 Free PMC article.
-
Chromosomal assignment of the endogenous proto-oncogene C-abl.Science. 1982 Dec 24;218(4579):1317-9. doi: 10.1126/science.6293057. Science. 1982. PMID: 6293057
Cited by
-
bcr/abl and src but not myc and ras replace v-abl in lymphoid transformation.Mol Cell Biol. 1990 Aug;10(8):4365-9. doi: 10.1128/mcb.10.8.4365-4369.1990. Mol Cell Biol. 1990. PMID: 2164639 Free PMC article.
-
Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.Proc Natl Acad Sci U S A. 1990 Sep;87(17):6649-53. doi: 10.1073/pnas.87.17.6649. Proc Natl Acad Sci U S A. 1990. PMID: 2204061 Free PMC article.
-
Lymphoid cells transformed by Abelson virus require the v-abl protein-tyrosine kinase only during early G1.Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6683-7. doi: 10.1073/pnas.89.15.6683. Proc Natl Acad Sci U S A. 1992. PMID: 1379715 Free PMC article.
-
Comparative Characterization of Osteoclasts Derived From Murine Bone Marrow Macrophages and RAW 264.7 Cells Using Quantitative Proteomics.JBMR Plus. 2018 Jul 7;2(6):328-340. doi: 10.1002/jbm4.10058. eCollection 2018 Nov. JBMR Plus. 2018. PMID: 30460336 Free PMC article.
-
Overview of RAW264.7 for osteoclastogensis study: Phenotype and stimuli.J Cell Mol Med. 2019 May;23(5):3077-3087. doi: 10.1111/jcmm.14277. Epub 2019 Mar 20. J Cell Mol Med. 2019. PMID: 30892789 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Other Literature Sources
Miscellaneous