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Review
. 2017:223:49-75.
doi: 10.1007/978-3-319-53168-7_3.

Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease

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Review

Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease

Evelyn A Kurt-Jones et al. Adv Anat Embryol Cell Biol. 2017.

Abstract

Innate immune responses play a major role in the control of herpes simplex virus (HSV) infections, and a multiplicity of mechanisms have emerged as a result of human evolution to sense and respond to HSV infections. HSV in turn has evolved a number of ways to evade immune detection and to blunt human innate immune responses. In this review, we summarize the major host innate immune mechanisms and the HSV evasion mechanisms that have evolved. We further discuss how disease can result if this equilibrium between virus and host response is disrupted.

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Figures

Figure 1.
Figure 1.
Antiviral Innate Immunity: Detection of viruses by pattern recognition receptors (Copyright, Evelyn Kurt-Jones and David Knipe)
Figure 2.
Figure 2.
Major innate immune sensor pathways engaged by HSV-1

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