Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jul;42(7):531-542.
doi: 10.1016/j.tibs.2017.04.003. Epub 2017 May 5.

Mechanisms Regulating PRC2 Recruitment and Enzymatic Activity

Daniel Holoch  1 , Raphaël Margueron  2
Affiliations
Review

Mechanisms Regulating PRC2 Recruitment and Enzymatic Activity

Daniel Holoch et al. Trends Biochem Sci. 2017 Jul.

Abstract

Polycomb repressive complex 2 (PRC2) and its histone H3 lysine-27 methylation activity are crucial for multicellular development by virtue of their role in maintaining transcriptional repression patterns. The recruitment and enzymatic activity of PRC2 are controlled by a series of intricate mechanisms whose molecular details have been emerging at a rapid pace. Recent studies have uncovered intriguing modes of PRC2 regulation by facultative PRC2 subunits, PRC1, and specific features of the chromatin environment. Together, these findings have produced a rich and fast-evolving picture of the biochemical signals that govern PRC2 function, with many exciting questions still remaining.

Keywords: H3K27me3; PRC1; PRC2; PRC2 facultative subunits; PRC2 regulation; transcriptional repression.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

Substances

LinkOut - more resources