Assessment of Glomerular Filtration Rate in Health and Disease: A State of the Art Review
- PMID: 28474735
- DOI: 10.1002/cpt.729
Assessment of Glomerular Filtration Rate in Health and Disease: A State of the Art Review
Abstract
Acute and chronic kidney diseases affect pharmacokinetics and pharmacodynamics. There has been substantial progress in the past 20 years in the use of glomerular filtration rate (GFR) estimating equations. In principle, use of a single equation for each filtration marker (creatinine, cystatin C, or the combination) for detection, evaluation, and management of kidney disease and for drug development and dosing would facilitate clinical practice. We review the principles for assessment of GFR, provide historical perspectives and updates regarding use of GFR estimating equations, including assay methods for filtration markers, performance of estimating equations, and recommendations by clinical practice guideline groups and regulatory agencies. We conclude that it is time to change from rigid adherence to the use of the Cockcroft-Gault equation for use in drug development and drug dosing to the more accurate and more widely used Modification of Diet in Renal Disease (MDRD) study and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations.
© 2017 American Society for Clinical Pharmacology and Therapeutics.
Similar articles
-
Comparing Results of Five Glomerular Filtration Rate-Estimating Equations in the Korean General Population: MDRD Study, Revised Lund-Malmö, and Three CKD-EPI Equations.Ann Lab Med. 2016 Nov;36(6):521-8. doi: 10.3343/alm.2016.36.6.521. Ann Lab Med. 2016. PMID: 27578504 Free PMC article.
-
Cystatin C- and creatinine-based equations in the assessment of renal function in HIV-positive patients prior to commencing Highly Active Antiretroviral Therapy.Ann Clin Biochem. 2016 Jan;53(Pt 1):58-66. doi: 10.1177/0004563215579695. Epub 2015 Mar 12. Ann Clin Biochem. 2016. PMID: 25766385
-
Kidney function estimating equations in patients with chronic kidney disease.Int J Clin Pract. 2011 Apr;65(4):458-64. doi: 10.1111/j.1742-1241.2010.02597.x. Int J Clin Pract. 2011. PMID: 21401834
-
Creatinine-based formulae for estimating glomerular filtration rate: is it time to change to chronic kidney disease epidemiology collaboration equation?Curr Opin Nephrol Hypertens. 2011 Nov;20(6):622-30. doi: 10.1097/MNH.0b013e32834ba210. Curr Opin Nephrol Hypertens. 2011. PMID: 21941179 Review.
-
Understanding kidney function assessment: the basics and advances.J Am Assoc Nurse Pract. 2013 Jul;25(7):334-41. doi: 10.1002/2327-6924.12024. Epub 2013 May 13. J Am Assoc Nurse Pract. 2013. PMID: 24170616 Review.
Cited by
-
Dihydropyrimidine dehydrogenase phenotype in peripheral blood mononuclear cells is related to adverse events of fluoropyrimidine-therapy.Eur J Clin Pharmacol. 2023 Apr;79(4):493-501. doi: 10.1007/s00228-023-03466-8. Epub 2023 Feb 9. Eur J Clin Pharmacol. 2023. PMID: 36757428
-
Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome.Kidney Res Clin Pract. 2021 Jun;40(2):220-230. doi: 10.23876/j.krcp.20.210. Epub 2021 Jun 9. Kidney Res Clin Pract. 2021. PMID: 34162048 Free PMC article.
-
Measurement and Estimation of Glomerular Filtration Rate in Children.Adv Chronic Kidney Dis. 2017 Nov;24(6):348-356. doi: 10.1053/j.ackd.2017.09.011. Adv Chronic Kidney Dis. 2017. PMID: 29229165 Free PMC article. Review.
-
Comparison of plasma clearance of [51Cr]CrEDTA based on three, two and single samples to measure the glomerular filtration rate in patients with solid tumors: a prospective cross-sectional analysis.Clinics (Sao Paulo). 2024 Jun 29;79:100427. doi: 10.1016/j.clinsp.2024.100427. eCollection 2024. Clinics (Sao Paulo). 2024. PMID: 38945113 Free PMC article.
-
Role of Estimated Glomerular Filtration Rate in Clinical Research: The Never-Ending Matter.Rev Cardiovasc Med. 2024 Jan 4;25(1):1. doi: 10.31083/j.rcm2501001. eCollection 2024 Jan. Rev Cardiovasc Med. 2024. PMID: 39077647 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
