Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide
- PMID: 2845276
- DOI: 10.1038/335639a0
Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide
Abstract
The clinical manifestations of AIDS (acquired immune deficiency syndrome) often include neuropsychiatric and neurological deficits, including early memory loss and progressive dementia. HIV (human immunodeficiency virus), the aetiological agent of AIDS, is probably carried by infected macrophages in the central nervous system. The virus enters cells by binding its envelope glycoprotein gp120 to the CD4 antigen present on brain and immune cells. From the data reported in this paper, we now suggest that the neuronal deficits associated with HIV may not be entirely a result of infectivity, but that gp120 shed from HIV could directly produce the neuropathology as a result of its interference with endogenous neurotrophic substances. It is known that an analogue of a sequence contained in vasoactive intestinal peptide (VIP) occurs in all known sequenced gp120 isolates and that VIP is important for neuronal survival in cell culture. Here we show that purified gp120 from two diverse HIV isolates and a recombinant gp120 from a third isolate were all potent in specifically producing significant neuronal cell death in dissociated hippocampal cultures derived from fetal mice, and that this could be reduced by monoclonal antibodies against the murine CD4 antigen and completely antagonized by VIP.
Similar articles
-
The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4.Nature. 1988 Jul 14;334(6178):159-62. doi: 10.1038/334159a0. Nature. 1988. PMID: 3260352
-
[AIDS and sleep disorders: effect of gp120 on cerebral glucose metabolism].C R Seances Soc Biol Fil. 1989;183(5):407-18. C R Seances Soc Biol Fil. 1989. PMID: 2561668 French.
-
Inhibition of murine embryonic growth by human immunodeficiency virus envelope protein and its prevention by vasoactive intestinal peptide and activity-dependent neurotrophic factor.J Clin Invest. 1997 Jun 15;99(12):2837-41. doi: 10.1172/JCI119476. J Clin Invest. 1997. PMID: 9185505 Free PMC article.
-
Characterization of CD4 glycoprotein determinant-HIV envelope protein interactions: perspectives for analog and vaccine development.Crit Rev Immunol. 1988;8(4):315-39. Crit Rev Immunol. 1988. PMID: 2850890 Review.
-
gp120 as an etiologic agent for NeuroAIDS: neurotoxicity and model systems.Adv Neuroimmunol. 1994;4(3):157-65. doi: 10.1016/s0960-5428(06)80252-4. Adv Neuroimmunol. 1994. PMID: 7874383 Review.
Cited by
-
Morphine efficacy is altered in conditional HIV-1 Tat transgenic mice.Eur J Pharmacol. 2012 Aug 15;689(1-3):96-103. doi: 10.1016/j.ejphar.2012.05.029. Epub 2012 May 30. Eur J Pharmacol. 2012. PMID: 22659585 Free PMC article.
-
Methamphetamine enhancement of HIV-1 gp120-mediated NLRP3 inflammasome activation and resultant proinflammatory responses in rat microglial cultures.Res Sq [Preprint]. 2023 Dec 16:rs.3.rs-3707515. doi: 10.21203/rs.3.rs-3707515/v1. Res Sq. 2023. Update in: Int J Mol Sci. 2024 Mar 22;25(7):3588. doi: 10.3390/ijms25073588. PMID: 38168345 Free PMC article. Updated. Preprint.
-
Distribution of human immunodeficiency virus (HIV) in the CNS of children with severe HIV encephalomyelopathy.Acta Neuropathol. 1992;84(1):24-31. doi: 10.1007/BF00427211. Acta Neuropathol. 1992. PMID: 1502880
-
Beneficial and Adverse Effects of cART Affect Neurocognitive Function in HIV-1 Infection: Balancing Viral Suppression against Neuronal Stress and Injury.J Neuroimmune Pharmacol. 2021 Mar;16(1):90-112. doi: 10.1007/s11481-019-09868-9. Epub 2019 Aug 6. J Neuroimmune Pharmacol. 2021. PMID: 31385157 Free PMC article. Review.
-
Pathogenic mechanisms of neuronal damage in the AIDS dementia complex.Mol Pathol. 1997 Apr;50(2):72-6. doi: 10.1136/mp.50.2.72. Mol Pathol. 1997. PMID: 9231153 Free PMC article. Review. No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
