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. 1988 Jul;165(1):74-86.
doi: 10.1016/0042-6822(88)90660-5.

The genome of budgerigar fledgling disease virus, an avian polyomavirus

O Rott  1 , M Kröger, H Müller, G Hobom
Affiliations

The genome of budgerigar fledgling disease virus, an avian polyomavirus

O Rott et al. Virology. 1988 Jul.

Abstract

Budgerigar fledgling disease virus (BFDV) represents the first avian member of the Polyomavirus family. In contrast to mammalian polyomaviruses BFDV exhibits unique biological properties, in particular it is able to cause an acute disease with distinct organ manifestations in affected birds. Here we present the complete nucleotide sequence of the BFDV genome, consisting of 4980 bp. When compared to published nucleotide sequences of other polyomaviruses, the BFDV genome exposes a number of very similar structural features, and undoubtedly qualifies as a member of that family of viruses. The most important differences include a large T antigen remarkably reduced in size, and an origin of replication region with fundamental deviations from the origin structure of all other polyomaviruses. The specific characteristics of the BFDV genome may be used to place this virus into a distinct subgroup within the Polyomavirus family and may give a clue to the elucidation of its extraordinary biological properties.

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