Diversity and functions of intestinal mononuclear phagocytes

doi:10.1038/mi.2017.22

Review

. 2017 Jul;10(4):845-864.

doi: 10.1038/mi.2017.22. Epub 2017 Apr 5.

Diversity and functions of intestinal mononuclear phagocytes

T Joeris^{1

2}, K Müller-Luda², W W Agace^{1

2}, A McI Mowat³

Affiliations

¹ Section of Immunology and Vaccinology, Danish Technical University Veterinary Institute, Copenhagen, Denmark.
² Section of Immunology, Department of Experimental Medical Science, Lund University, Lund, Sweden.
³ Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, UK.

PMID: 28378807
DOI: 10.1038/mi.2017.22

Free article

Review

Diversity and functions of intestinal mononuclear phagocytes

T Joeris et al. Mucosal Immunol. 2017 Jul.

Free article

. 2017 Jul;10(4):845-864.

doi: 10.1038/mi.2017.22. Epub 2017 Apr 5.

Authors

T Joeris^{1

2}, K Müller-Luda², W W Agace^{1

2}, A McI Mowat³

Affiliations

¹ Section of Immunology and Vaccinology, Danish Technical University Veterinary Institute, Copenhagen, Denmark.
² Section of Immunology, Department of Experimental Medical Science, Lund University, Lund, Sweden.
³ Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, UK.

PMID: 28378807
DOI: 10.1038/mi.2017.22

Abstract

The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP) subsets, including conventional dendritic cells (cDC), monocytes and tissue-resident macrophages (mφ) that collectively play an essential role in mucosal homeostasis, infection and inflammation. In the current review we discuss the function of intestinal cDC and monocyte-derived MNP, highlighting how these subsets play several non-redundant roles in the regulation of intestinal immune responses. While much remains to be learnt, recent findings also underline how the various populations of MNP adapt to deal with the challenges specific to their environment. Understanding these processes should help target individual subsets for 'fine tuning' immunological responses within the intestine, a process that may be of relevance both for the treatment of inflammatory bowel disease (IBD) and for optimized vaccine design.

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References

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[1] Immunity. 2013 Mar 21;38(3):581-95 - PubMed

[2] Immunity. 2013 Mar 21;38(3):581-95 - PubMed

[3] J Exp Med. 2014 Apr 7;211(4):623-33 - PubMed

[4] J Exp Med. 2014 Apr 7;211(4):623-33 - PubMed

[5] J Immunol. 2010 Mar 1;184(5):2671-6 - PubMed

[6] J Immunol. 2010 Mar 1;184(5):2671-6 - PubMed

[7] J Exp Med. 2009 Dec 21;206(13):3101-14 - PubMed

[8] J Exp Med. 2009 Dec 21;206(13):3101-14 - PubMed

[9] J Immunol. 2016 Jun 1;196 (11):4739-49 - PubMed

[10] J Immunol. 2016 Jun 1;196 (11):4739-49 - PubMed

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Diversity and functions of intestinal mononuclear phagocytes

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Diversity and functions of intestinal mononuclear phagocytes

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