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. 2017 Mar 7:8:376.
doi: 10.3389/fmicb.2017.00376. eCollection 2017.

Shaping the Metabolism of Intestinal Bacteroides Population through Diet to Improve Human Health

David Rios-Covian  1 , Nuria Salazar  1 , Miguel Gueimonde  1 , Clara G de Los Reyes-Gavilan  1
Affiliations

Shaping the Metabolism of Intestinal Bacteroides Population through Diet to Improve Human Health

David Rios-Covian et al. Front Microbiol. .
No abstract available

Keywords: Bacteroides; branched-chain amino acids; diet; human metabolism; intestinal microbiota; propionate; short chain fatty acids.

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Figures

Figure 1
Figure 1
The metabolic versatility of Bacteroides and the modulation of its metabolism through diet may impact human health. (A) The relative proportions of the different organic acids and SCFA produced by cultures of Bacteroides fragilis at 24 h of incubation in non-defined peptone and yeast extract containing medium (BM; Rios-Covian et al., 2015) and in minimal medium without no organic nitrogen source (MM; Rios-Covian et al., 2016b) and supplemented with glucose, or with exopolysaccharides produced by Bifidobacterium strains (EPS E44 and EPS R1), are represented in shaded circles. The table at the top right side indicates total concentration (mM) of SCFA plus organic acids produced by B. fragilis in the different culture conditions. (B) Schematic representation of catabolic routes for the formation of SCFA and organic acids by B. fragilis. Thick bold arrows indicate pathways probably favored in MM supplemented with glucose (left side) or in BM supplemented with bacterial EPS (right side). (C) Schematic representation of the general hypothesis on how re-shaping the intestinal Bacteroides metabolism through the adequate balance of dietary proteins and carbohydrates could influence human health. On the one hand, changes occurring in the profile of SCFA and organic acids produced by this bacterium could act on the host carbohydrates and lipids metabolism directly or through cross-feeding or other microbial interaction mechanisms. On the other hand, the metabolism of intestinal Bacteroides may modify blood circulating amino acids in the host, which have been related with some metabolic disorders. OAA, oxaloacetate; SCFA, short chain fatty acidis; BCAA, branched chain amino acids; PEP, phosphoenolpyruvate.
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