Anti-inflammatory properties of anesthetic agents

doi:10.1186/s13054-017-1645-x

Review

. 2017 Mar 21;21(1):67.

doi: 10.1186/s13054-017-1645-x.

Anti-inflammatory properties of anesthetic agents

Fernanda Ferreira Cruz¹, Patricia Rieken Macedo Rocco¹, Paolo Pelosi²

Affiliations

¹ Federal University of Rio de Janeiro, Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, 21941-902, Rio de Janeiro, Brazil.
² Department of Surgical Sciences and Integrated Diagnostics, IRCCS AOU San Martino IST, University of Genoa, 16132, Genoa, Italy. ppelosi@hotmail.com.

PMID: 28320449
PMCID: PMC5359894
DOI: 10.1186/s13054-017-1645-x

Review

Anti-inflammatory properties of anesthetic agents

Fernanda Ferreira Cruz et al. Crit Care. 2017.

. 2017 Mar 21;21(1):67.

doi: 10.1186/s13054-017-1645-x.

Authors

Fernanda Ferreira Cruz¹, Patricia Rieken Macedo Rocco¹, Paolo Pelosi²

Affiliations

¹ Federal University of Rio de Janeiro, Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, 21941-902, Rio de Janeiro, Brazil.
² Department of Surgical Sciences and Integrated Diagnostics, IRCCS AOU San Martino IST, University of Genoa, 16132, Genoa, Italy. ppelosi@hotmail.com.

PMID: 28320449
PMCID: PMC5359894
DOI: 10.1186/s13054-017-1645-x

Abstract

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at http://ccforum.com/series/annualupdate2017 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901 .

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Figures

**Fig. 1**
Schematic diagram of possible modulators of immune competence during anesthesia and surgery. Anesthetics have direct effects on the immune system and indirect effects through neuro-immune-endocrine interactions during surgical stress

See this image and copyright information in PMC

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References

1. Kurosawa S, Kato M. Anesthetics, immune cells, and immune responses. J Anesth. 2008;22:263–277. doi: 10.1007/s00540-008-0626-2. - DOI - PubMed
1. Colucci DG, Puig NR, Hernandez PR. Influence of anesthetic drugs on immune response: from inflammation to immunosuppression. OA Anesthetics. 2013;1:21–38.
1. Friedman H, Newton C, Klein TW. Microbial Infections, Immunomodulation, and Drugs of Abuse. Clin Microbiol Rev. 2003;16(2):209–219. doi: 10.1128/CMR.16.2.209-219.2003. - DOI - PMC - PubMed
1. Schneemilch CE, Schilling T, Bank U. Effects of general anaesthesia on inflammation. Best Pract Res Clin Anaesthesiol. 2004;18:493–507. doi: 10.1016/j.bpa.2004.01.002. - DOI - PubMed
1. Elenkov IJ, Chrousos GP. Stress hormones, proinflammtory and anti-inflammatory cytokines, and autoimmunity. Ann NY Acad Sci. 2002;966:290–303. doi: 10.1111/j.1749-6632.2002.tb04229.x. - DOI - PubMed

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[1] Kurosawa S, Kato M. Anesthetics, immune cells, and immune responses. J Anesth. 2008;22:263–277. doi: 10.1007/s00540-008-0626-2. - DOI - PubMed

[2] Kurosawa S, Kato M. Anesthetics, immune cells, and immune responses. J Anesth. 2008;22:263–277. doi: 10.1007/s00540-008-0626-2. - DOI - PubMed

[3] Colucci DG, Puig NR, Hernandez PR. Influence of anesthetic drugs on immune response: from inflammation to immunosuppression. OA Anesthetics. 2013;1:21–38.

[4] Colucci DG, Puig NR, Hernandez PR. Influence of anesthetic drugs on immune response: from inflammation to immunosuppression. OA Anesthetics. 2013;1:21–38.

[5] Friedman H, Newton C, Klein TW. Microbial Infections, Immunomodulation, and Drugs of Abuse. Clin Microbiol Rev. 2003;16(2):209–219. doi: 10.1128/CMR.16.2.209-219.2003. - DOI - PMC - PubMed

[6] Friedman H, Newton C, Klein TW. Microbial Infections, Immunomodulation, and Drugs of Abuse. Clin Microbiol Rev. 2003;16(2):209–219. doi: 10.1128/CMR.16.2.209-219.2003. - DOI - PMC - PubMed

[7] Schneemilch CE, Schilling T, Bank U. Effects of general anaesthesia on inflammation. Best Pract Res Clin Anaesthesiol. 2004;18:493–507. doi: 10.1016/j.bpa.2004.01.002. - DOI - PubMed

[8] Schneemilch CE, Schilling T, Bank U. Effects of general anaesthesia on inflammation. Best Pract Res Clin Anaesthesiol. 2004;18:493–507. doi: 10.1016/j.bpa.2004.01.002. - DOI - PubMed

[9] Elenkov IJ, Chrousos GP. Stress hormones, proinflammtory and anti-inflammatory cytokines, and autoimmunity. Ann NY Acad Sci. 2002;966:290–303. doi: 10.1111/j.1749-6632.2002.tb04229.x. - DOI - PubMed

[10] Elenkov IJ, Chrousos GP. Stress hormones, proinflammtory and anti-inflammatory cytokines, and autoimmunity. Ann NY Acad Sci. 2002;966:290–303. doi: 10.1111/j.1749-6632.2002.tb04229.x. - DOI - PubMed

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Anti-inflammatory properties of anesthetic agents

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Anti-inflammatory properties of anesthetic agents

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