Runx3 in Immunity, Inflammation and Cancer
- PMID: 28299669
- DOI: 10.1007/978-981-10-3233-2_23
Runx3 in Immunity, Inflammation and Cancer
Abstract
In this chapter we summarize the pros and cons of the notion that Runx3 is a major tumor suppressor gene (TSG). Inactivation of TSGs in normal cells provides a viability/growth advantage that contributes cell-autonomously to cancer. More than a decade ago it was suggested that RUNX3 is involved in gastric cancer development, a postulate extended later to other epithelial cancers portraying RUNX3 as a major TSG. However, evidence that Runx3 is not expressed in normal gastric and other epithelia has challenged the RUNX3-TSG paradigm. In contrast, RUNX3 is overexpressed in a significant fraction of tumor cells in various human epithelial cancers and its overexpression in pancreatic cancer cells promotes their migration, anchorage-independent growth and metastatic potential. Moreover, recent high-throughput quantitative genome-wide studies on thousands of human samples of various tumors and new investigations of the role of Runx3 in mouse cancer models have unequivocally demonstrated that RUNX3 is not a bona fide cell-autonomous TSG. Importantly, accumulating data demonstrated that RUNX3 functions in control of immunity and inflammation, thereby indirectly influencing epithelial tumor development.
Keywords: Cancer; Immunity; Inflammation; RUNX3; Tumor suppressor gene.
Similar articles
-
Runx3 at the interface of immunity, inflammation and cancer.Biochim Biophys Acta. 2015 Apr;1855(2):131-43. doi: 10.1016/j.bbcan.2015.01.004. Epub 2015 Jan 30. Biochim Biophys Acta. 2015. PMID: 25641675 Review.
-
The emerging role of RUNX3 in cancer metastasis (Review).Oncol Rep. 2016 Mar;35(3):1227-36. doi: 10.3892/or.2015.4515. Epub 2015 Dec 24. Oncol Rep. 2016. PMID: 26708741 Review.
-
Molecular pathology of RUNX3 in human carcinogenesis.Biochim Biophys Acta. 2009 Dec;1796(2):315-31. doi: 10.1016/j.bbcan.2009.07.004. Epub 2009 Aug 12. Biochim Biophys Acta. 2009. PMID: 19682550 Review.
-
Epigenetic inactivation of the RUNX3 gene in lung cancer.Oncol Rep. 2006 Jan;15(1):129-35. Oncol Rep. 2006. PMID: 16328045
-
Runx3 controls growth and differentiation of gastric epithelial cells in mammals.Dev Growth Differ. 2006 Jan;48(1):1-13. doi: 10.1111/j.1440-169X.2006.00832.x. Dev Growth Differ. 2006. PMID: 16466388 Review.
Cited by
-
RUNX3-dependent oxidative epithelial-to-mesenchymal transition in methamphetamine-induced chronic lung injury.Cell Stress Chaperones. 2020 Sep;25(5):793-802. doi: 10.1007/s12192-020-01133-w. Epub 2020 Jul 17. Cell Stress Chaperones. 2020. PMID: 32681471 Free PMC article.
-
Characterization and clinical evaluation of microsatellite instability and loss of heterozygosity in tumor-related genes in gastric cancer.Oncol Lett. 2021 Jun;21(6):430. doi: 10.3892/ol.2021.12691. Epub 2021 Mar 30. Oncol Lett. 2021. PMID: 33868468 Free PMC article.
-
Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night.Mol Cells. 2020 Feb 29;43(2):188-197. doi: 10.14348/molcells.2019.0310. Mol Cells. 2020. PMID: 32041394 Free PMC article. Review.
-
Identification of RUNX1 and IFNGR2 as prognostic-related biomarkers correlated with immune infiltration and subtype differentiation of low-grade glioma.Biomol Biomed. 2023 May 1;23(3):405-425. doi: 10.17305/bjbms.2022.8086. Biomol Biomed. 2023. PMID: 36321611 Free PMC article.
-
TREML4 polymorphisms increase the mRNA in blood leukocytes in the progression of atherosclerosis.Sci Rep. 2022 Nov 3;12(1):18612. doi: 10.1038/s41598-022-22040-3. Sci Rep. 2022. PMID: 36329152 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
