Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jan;62(1):206-10.
doi: 10.1128/JVI.62.1.206-210.1988.

Adenovirus E1B 55-Mr polypeptide facilitates timely cytoplasmic accumulation of adeno-associated virus mRNAs

R J Samulski  1 , T Shenk
Affiliations

Adenovirus E1B 55-Mr polypeptide facilitates timely cytoplasmic accumulation of adeno-associated virus mRNAs

R J Samulski et al. J Virol. 1988 Jan.

Abstract

Adenovirus provides helper functions that facilitate replication of adeno-associated virus (AAV). Both the adenovirus E1B 55-Mr and E4 34-Mr polypeptides are required for efficient and timely accumulation of AAV mRNA, proteins, and DNA. The E1B 55-Mr polypeptide is also required for rescue of the integrated AAV genome in Detroit 6-D5 cells in a normal time frame. All of these effects probably result from a single, primary delay in AAV mRNA accumulation. The AAV helper function provided by the E1B 55-Mr and E4 34-Mr polypeptides appears to closely parallel their normal role in the adenovirus replication cycle.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Virology. 1980 Jul 30;104(2):502-5 - PubMed
    1. Cell. 1980 May;20(1):95-105 - PubMed
    1. Cold Spring Harb Symp Quant Biol. 1980;44 Pt 1,:367-75 - PubMed
    1. Proc Natl Acad Sci U S A. 1981 Mar;78(3):1925-9 - PubMed
    1. J Virol. 1981 Oct;40(1):241-7 - PubMed

Publication types

LinkOut - more resources