Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 May;254(3):1233-1240.
doi: 10.1007/s00709-017-1090-3. Epub 2017 Feb 24.

Function of heterochromatin protein 1 during DNA repair

Eva Bártová  1 , Barbora Malyšková  2 , Denisa Komůrková  2 , Soňa Legartová  2 , Jana Suchánková  2 , Jana Krejčí  2 , Stanislav Kozubek  2
Affiliations
Review

Function of heterochromatin protein 1 during DNA repair

Eva Bártová et al. Protoplasma. 2017 May.

Abstract

This review focuses on the function of heterochromatin protein HP1 in response to DNA damage. We specifically outline the regulatory mechanisms in which HP1 and its interacting partners are involved. HP1 protein subtypes (HP1α, HP1β, and HP1γ) are the main components of constitutive heterochromatin, and HP1α and HP1β in particular are responsible for heterochromatin maintenance. The recruitment of these proteins to DNA lesions is also important from the perspective of proper DNA repair mechanisms. For example, HP1α is necessary for the binding of the main DNA damage-related protein 53BP1 at DNA repair foci, which are positive not only for the HP1α protein but also for the RAD51 protein, a component of DNA repair machinery. The HP1β protein also appears in monomeric form in DNA lesions together with the evolutionarily well-conserved protein called proliferating cell nuclear antigen (PCNA). The role of HP1 in DNA lesions is also mediated via the Kap1 transcription repressor. Taken together, these results indicate that the function of HP1 after DNA injury depends strongly on the kinetics of other DNA repair-related factors and their post-translational modifications, such as the phosphorylation of Kap-1.

Keywords: DNA damage response; DNA repair; HP1 protein.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12183-8 - PubMed
    1. Cytometry A. 2009 Jul;75(7):619-25 - PubMed
    1. Nat Cell Biol. 2010 Feb;12 (2):177-84 - PubMed
    1. Nucleic Acids Res. 2015 Sep 18;43(16):7931-44 - PubMed
    1. Cell Cycle. 2012 Jun 1;11(11):2170-5 - PubMed

MeSH terms

LinkOut - more resources