Evaluation of an injectable bioactive borate glass cement to heal bone defects in a rabbit femoral condyle model

doi:10.1016/j.msec.2016.12.101

. 2017 Apr 1:73:585-595.

doi: 10.1016/j.msec.2016.12.101. Epub 2016 Dec 22.

Evaluation of an injectable bioactive borate glass cement to heal bone defects in a rabbit femoral condyle model

Xu Cui¹, Wenhai Huang², Yadong Zhang³, Chengcheng Huang⁴, Zunxiong Yu⁴, Lei Wang⁴, Wenlong Liu⁴, Ting Wang⁴, Jie Zhou², Hui Wang², Nai Zhou², Deping Wang², Haobo Pan⁵, Mohamed N Rahaman⁶

Affiliations

¹ Institute of Bioengineering and Information Technology Materials, Tongji University, Shanghai 200092, China; Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen 518055, China.
² Institute of Bioengineering and Information Technology Materials, Tongji University, Shanghai 200092, China.
³ Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China. Electronic address: zhangyadong6@126.com.
⁴ Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen 518055, China.
⁵ Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen 518055, China. Electronic address: hb.pan@siat.ac.cn.
⁶ Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China; Department of Materials Science and Engineering, Missouri University of Science and Technology, Rolla, MO 65409-0340, USA. Electronic address: rahaman@mst.edu.

PMID: 28183648
DOI: 10.1016/j.msec.2016.12.101

Evaluation of an injectable bioactive borate glass cement to heal bone defects in a rabbit femoral condyle model

Xu Cui et al. Mater Sci Eng C Mater Biol Appl. 2017.

. 2017 Apr 1:73:585-595.

doi: 10.1016/j.msec.2016.12.101. Epub 2016 Dec 22.

Authors

Affiliations

¹ Institute of Bioengineering and Information Technology Materials, Tongji University, Shanghai 200092, China; Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen 518055, China.
² Institute of Bioengineering and Information Technology Materials, Tongji University, Shanghai 200092, China.
³ Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China. Electronic address: zhangyadong6@126.com.
⁴ Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen 518055, China.
⁵ Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen 518055, China. Electronic address: hb.pan@siat.ac.cn.
⁶ Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China; Department of Materials Science and Engineering, Missouri University of Science and Technology, Rolla, MO 65409-0340, USA. Electronic address: rahaman@mst.edu.

PMID: 28183648
DOI: 10.1016/j.msec.2016.12.101

Abstract

There is a need for synthetic biomaterials to heal bone defects using minimal invasive surgery. In the present study, an injectable cement composed of bioactive borate glass particles and a chitosan bonding solution was developed and evaluated for its capacity to heal bone defects in a rabbit femoral condyle model. The injectability and setting time of the cement in vitro decreased but the compressive strength increased (8±2MPa to 31±2MPa) as the ratio of glass particles to chitosan solution increased (from 1.0gml^-1 to 2.5gml^-1). Upon immersing the cement in phosphate-buffered saline, the glass particles reacted and converted to hydroxyapatite, imparting bioactivity to the cement. Osteoblastic MC3T3-E1 cells showed enhanced proliferation and alkaline phosphatase activity when incubated in media containing the soluble ionic product of the cement. The bioactive glass cement showed a better capacity to stimulate bone formation in rabbit femoral condyle defects at 12weeks postimplantation when compared to a commercial calcium sulfate cement. The injectable bioactive borate glass cement developed in this study could provide a promising biomaterial to heal bone defects by minimal invasive surgery.

Keywords: Bioactive borate glass; Bone cement; Bone repair; Injectable bioactive glass cement; Rabbit femoral condyle model.

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Evaluation of an injectable bioactive borate glass cement to heal bone defects in a rabbit femoral condyle model

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Evaluation of an injectable bioactive borate glass cement to heal bone defects in a rabbit femoral condyle model

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