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. 2017 Mar;29(11).
doi: 10.1002/adma.201605375. Epub 2017 Jan 23.

Biomimetic Engineering Using Cancer Cell Membranes for Designing Compartmentalized Nanoreactors with Organelle-Like Functions

Vimalkumar Balasubramanian  1 , Alexandra Correia  1 , Hongbo Zhang  1   2 , Flavia Fontana  1 , Ermei Mäkilä  3 , Jarno Salonen  3 , Jouni Hirvonen  1 , Hélder A Santos  1
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Biomimetic Engineering Using Cancer Cell Membranes for Designing Compartmentalized Nanoreactors with Organelle-Like Functions

Vimalkumar Balasubramanian et al. Adv Mater. 2017 Mar.

Abstract

A new biomimetic nanoreactor design is presented based on cancer cell membrane material in combination with porous silicon nanoparticles. This cellular nanoreactor features a biocompartment enclosed by a cell membrane and readily integrated with cells and supplementing the cellular functions under oxidative stress. The study demonstrates the impact of the nanoreactors on improving cellular functions with a potential to serve as artificial organelles.

Keywords: artificial organelles; biocompartmentalization; biomimetic materials; nanoreactors; porous silicon nanoparticles.

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