Virus-induced hepatocellular carcinoma with special emphasis on HBV

doi:10.1007/s12072-016-9779-5

Review

. 2017 Mar;11(2):171-180.

doi: 10.1007/s12072-016-9779-5. Epub 2017 Jan 17.

Virus-induced hepatocellular carcinoma with special emphasis on HBV

Ming Wang¹, Dong Xi¹, Qin Ning²

Affiliations

¹ Department of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, No 1095, Jiefang Avenue, Wuhan, 430030, China.
² Department of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, No 1095, Jiefang Avenue, Wuhan, 430030, China. qning@vip.sina.com.

PMID: 28097530
DOI: 10.1007/s12072-016-9779-5

Review

Virus-induced hepatocellular carcinoma with special emphasis on HBV

Ming Wang et al. Hepatol Int. 2017 Mar.

. 2017 Mar;11(2):171-180.

doi: 10.1007/s12072-016-9779-5. Epub 2017 Jan 17.

Authors

Ming Wang¹, Dong Xi¹, Qin Ning²

Affiliations

¹ Department of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, No 1095, Jiefang Avenue, Wuhan, 430030, China.
² Department of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, No 1095, Jiefang Avenue, Wuhan, 430030, China. qning@vip.sina.com.

PMID: 28097530
DOI: 10.1007/s12072-016-9779-5

Abstract

Hepatocellular carcinoma (HCC) is a common malignant tumor with high lethality, and the hepatitis B virus (HBV) is a chief cause. HBV can accelerate HCC via multiple mechanisms. First, HBV induces immune reactions that lead to repeated hepatic inflammation, fibrosis and a deficient immune microenvironment. Subsequently, HBV can modify host genes near the insertion point through DNA integration to cause host cell genome instability and to generate carcinogenic fusion proteins. Additionally, HBV expresses diverse active proteins, especially HBx and HBs, which have a range of transactivation functions such as regulation of apoptosis, interference with intracellular signaling pathways, and alteration of epigenetics. Currently, primary prevention measures for HBV-induced HCC focus on vaccination and antiviral treatment. Here, we report the epidemiology, the molecular mechanism and the progress in therapeutic strategies for controlling HBV-induced HCC.

Keywords: HBV-induced HCC; Hepatitis B virus; Hepatocellular carcinoma.

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[1] Semin Cancer Biol. 2014 Jun;26:78-88 - PubMed

[2] Semin Cancer Biol. 2014 Jun;26:78-88 - PubMed

[3] World J Gastroenterol. 2015 Jan 7;21(1):311-7 - PubMed

[4] World J Gastroenterol. 2015 Jan 7;21(1):311-7 - PubMed

[5] Gastroenterology. 2016 Apr;150(4):835-53 - PubMed

[6] Gastroenterology. 2016 Apr;150(4):835-53 - PubMed

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[8] Hepatology. 2011 Mar;53(3):1020-2 - PubMed

[9] J Gastroenterol Hepatol. 2013 Aug;28 Suppl 1:7-10 - PubMed

[10] J Gastroenterol Hepatol. 2013 Aug;28 Suppl 1:7-10 - PubMed

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Virus-induced hepatocellular carcinoma with special emphasis on HBV

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Virus-induced hepatocellular carcinoma with special emphasis on HBV

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