Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production

doi:10.1002/mc.22602

. 2017 May;56(5):1414-1426.

doi: 10.1002/mc.22602.

Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production

Xinfang Yu^{1

2

3}, Wei Li^{1

2

4}, Qipan Deng^{1

2}, Shuo You⁵, Haidan Liu⁵, Songling Peng^{1

2}, Xiaolan Liu^{1

2}, Jingchen Lu^{1

2}, Xiangjian Luo^{1

2}, Lifang Yang^{1

2}, Min Tang^{1

2}, Xinxian Weng^{1

2}, Wei Yi^{1

2}, Wenbin Liu³, Shengqi Wu³, Zhihui Ding⁶, Tao Feng⁷, Jian Zhou⁸, Jia Fan⁸, Ann M Bode⁹, Zigang Dong⁹, Jikai Liu⁷, Ya Cao^{1

2}

Affiliations

¹ Key Laboratory of Cancer Carcinogenesis and Invasion of Chinese Ministry of Education, Xiangya Hospital, Central South University, Hunan, China.
² Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan, China.
³ Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Hunan, China.
⁴ Department of radiology, The Third Xiangya Hospital of Central South University, Hunan, China.
⁵ The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
⁶ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China.
⁷ School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China.
⁸ Key Laboratory of Carcinogenesis of Chinese Ministry of Public Health, Liver Cancer Institute, Zhongshan Hospital, Shanghai, China.
⁹ The Hormel Institute, University of Minnesota, Austin, Minnesota.

PMID: 27996164
DOI: 10.1002/mc.22602

Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production

Xinfang Yu et al. Mol Carcinog. 2017 May.

. 2017 May;56(5):1414-1426.

doi: 10.1002/mc.22602.

Authors

Affiliations

¹ Key Laboratory of Cancer Carcinogenesis and Invasion of Chinese Ministry of Education, Xiangya Hospital, Central South University, Hunan, China.
² Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan, China.
³ Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Hunan, China.
⁴ Department of radiology, The Third Xiangya Hospital of Central South University, Hunan, China.
⁵ The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
⁶ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China.
⁷ School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China.
⁸ Key Laboratory of Carcinogenesis of Chinese Ministry of Public Health, Liver Cancer Institute, Zhongshan Hospital, Shanghai, China.
⁹ The Hormel Institute, University of Minnesota, Austin, Minnesota.

PMID: 27996164
DOI: 10.1002/mc.22602

Abstract

Neoalbaconol, derived from Albatrellus confluens, shows anti-cancer activities in the previously study, but its role in angiogenesis is unknown. Here, we determined whether neoalbaconol could attenuate angiogenesis and how does it occur. Data demonstrated that neoalbaconol could inhibit the proliferation of breast cancer cells and induce apoptosis. Also, neoalbaconol suppressed vascular endothelial growth factor (VEGF)-induced human umbilical vascular endothelial cells (HUVECs) proliferation, migration, invasion, and capillary-like tube formation in vitro and reduced tumor angiogenesis in vivo. VEGF receptor activation and the downstream signal transduction cascades activation were inhibited by neoalbaconol. Additionally, neoalbaconol blocked EGFR-mediated VEGF production. EGFR overexpression reversed the neoalbaconol-induced VEGF reduction, confirming the importance of the EGFR inhibition in anti-angiogenesis of neoalbaconol. Furthermore, neoalbaconol inhibited tumor growth and tumor angiogenesis in a breast cancer xenograft model in vivo. Taken together, these results indicate that neoalbaconol could inhibit tumor angiogenesis and growth through direct suppression effects on vascular endothelial cells and reduction of proangiogenic factors in cancer cells.

Keywords: EGFR; VEGF; angiogenesis; breast cancer; neoalbaconol.

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Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production

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Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production

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