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Review
. 2017 Jan 3;8(1):303-314.
doi: 10.18632/oncotarget.13863.

Prognostic value of increased KPNA2 expression in some solid tumors: A systematic review and meta-analysis

Li-Na Zhou  1   2 , Yue Tan  1   2 , Ping Li  1   2 , Ping Zeng  2 , Min-Bin Chen  2 , Ye Tian  1 , Ya-Qun Zhu  1
Affiliations
Review

Prognostic value of increased KPNA2 expression in some solid tumors: A systematic review and meta-analysis

Li-Na Zhou et al. Oncotarget. .

Abstract

Background: Karyopherin α2 (KPNA2), a member of the Karyopherin α family, has recently been reported to play an important role in tumor progression. However, the association between KPNA2 expression and prognosis in cancer remains controversial. So we performed this meta-analysis to evaluate whether expression of KPNA2 was associated with prognosis in patients with solid tumor.

Methods/findings: 24 published eligible studies, including 6164 cases, were identified and included in this meta-analysis through searching of PubMed, EMBASE and Web of Science. We found that KPNA2 expression was an independent predictor for the prognosis of solid tumor with primary outcome (overall survival [OS]: pooled HR=1.767, 95% CI=1.503-2.077, P<0.001) and secondary outcomes (time to recurrence [TTR], recurrence free survival [RFS] and progression free survival [PFS]). However, the association between KPNA2 overexpression and disease free survival [DFS] in solid tumors was not significant (pooled HR=1.653, 95% CI=0.903-3.029, P=0.104). Furthermore, the subgroup analysis revealed that KPNA2 overexpression was associated with poor OS in East-Asian patients and European patients, as well as patients with gastric and colorectal cancer.

Conclusion: KPNA2 expression may be a useful prognostic biomarker to monitor cancer prognosis. Further prospective studies with larger sample sizes are required to confirm our findings.

Keywords: KPNA2; overall survival; prognosis; tumor.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors have declared that there is no competing interest.

Figures

Figure 1
Figure 1. The flow chart of the selection process in our meta-analysis
Figure 2
Figure 2. The correlation between KPNA2 expression and overall survival in solid tumor
Figure 3
Figure 3. The correlation between KPNA2 expression and time to tumor progression in solid tumor
Figure 4
Figure 4. Begg's funnel plots for the studies involved in the meta-analysis of KPNA2 expression and the prognosis of patients with solid tumors
A. Publication bias influence on the overall effect was assessed by the Duval and Tweedie's trim and fill method Duval and Tweedie's trim and fill method B. Abbreviations: loghr, logarithm of hazard ratios; s.e., standard error.
Figure 5
Figure 5. Sensitivity analysis of the meta-analysis (Overall survival)
See this image and copyright information in PMC

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References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65:5–29. - PubMed
    1. Christiansen A, Dyrskjot L. The functional role of the novel biomarker karyopherin alpha 2 (KPNA2) in cancer. Cancer letters. 2013;331:18–23. - PMC - PubMed
    1. Wang CI, Chien KY, Wang CL, Liu HP, Cheng CC, Chang YS, Yu JS, Yu CJ. Quantitative proteomics reveals regulation of karyopherin subunit alpha-2 (KPNA2) and its potential novel cargo proteins in nonsmall cell lung cancer. Molecular & cellular proteomics. 2012;11:1105–1122. - PMC - PubMed
    1. Huang L, Wang HY, Li JD, Wang JH, Zhou Y, Luo RZ, Yun JP, Zhang Y, Jia WH, Zheng M. KPNA2 promotes cell proliferation and tumorigenicity in epithelial ovarian carcinoma through upregulation of c-Myc and downregulation of FOXO3a. Cell death & disease. 2013;4:e745. - PMC - PubMed
    1. Noetzel E, Rose M, Bornemann J, Gajewski M, Knuchel R, Dahl E. Nuclear transport receptor karyopherin-alpha2 promotes malignant breast cancer phenotypes in vitro. Oncogene. 2012;31:2101–2114. - PubMed