Characteristics of liver cirrhosis in Italy: Evidence for a decreasing role of HCV aetiology

doi:10.1016/j.ejim.2016.10.012

. 2017 Mar:38:68-72.

doi: 10.1016/j.ejim.2016.10.012. Epub 2016 Nov 9.

Characteristics of liver cirrhosis in Italy: Evidence for a decreasing role of HCV aetiology

Collaborators, Affiliations

Collaborators

EPACRON study group:
Piero Luigi Almasio, Giovanni Battista Gaeta, Evangelista Sagnelli, Tommaso Stroffolini, Angelo Andriulli, Sergio Babudieri⁹, Giuseppina Brancaccio, Bruno Cacopardo¹⁰, Guido Colloredo, Nicola Coppola², Massimo De Luca¹¹, Caterina Furlan, Anna Licata¹², Filomena Morisco, Mario Pirisi, Mariantonietta Pisaturo¹³, Floriano Rosina¹⁴, Maurizio Russello¹⁵, Caterina Sagnelli, Teresa Santantonio¹⁶, Antonina Smedile¹⁷

Affiliations

¹ Department of Tropical and Infectious Diseases, Policlinico Umberto Primo, Rome, Italy.
² Department of Mental Health and Public Medicine, Second University of Naples, Italy.
³ Infectious Diseases, Department of Mental and Physical Health and Preventive Medicine, Second University of Naples, Italy.
⁴ Gastroenterology Unit, Fondazione "Casa Sollievo della Sofferenza" IRCCS Hospital, San Giovanni Rotondo, Foggia, Italy.
⁵ Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy.
⁶ Department of Internal Medicine, San Pietro Hospital, Ponte San Pietro, Italy.
⁷ Department of Clinical Medicine and Surgery, Gastroenterology Unit, University of Naples "Federico II", Naples, Italy.
⁸ Gastroenterology & Hepatology Unit, Di. Bi.MI. S., University of Palermo, Italy. Electronic address: piero.almasio@unipa.it.
⁹ Clinical of Infectious Disease, University of Sassari, 07100 Sassari, Italy.
¹⁰ Infectious Diseases, University of Catania, Italy.
¹¹ Liver Unit, Department of Transplantation, Division of Hepatology, Cardarelli Hospital, Italy.
¹² Gastroenterology & Hepatology Unit, Di. Bi.MI. S., University of Palermo, Italy.
¹³ Division of Infectious Diseases, AORN Sant'Anna e San Sebastiano di Caserta, 81100 Caserta, Italy.
¹⁴ Hepatogastroenterology Division, Ospedale Gradenigo, 10153 Torino, Italy.
¹⁵ Liver Unit, Hospital "G. Garibaldi" Catania, Catania, Italy.
¹⁶ Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy.
¹⁷ Department of Gastroenterology, Molinette Hospital, C.so Bramante 88, 10126 Turin, Italy.

PMID: 27836249
DOI: 10.1016/j.ejim.2016.10.012

Characteristics of liver cirrhosis in Italy: Evidence for a decreasing role of HCV aetiology

Tommaso Stroffolini et al. Eur J Intern Med. 2017 Mar.

. 2017 Mar:38:68-72.

doi: 10.1016/j.ejim.2016.10.012. Epub 2016 Nov 9.

Collaborators

EPACRON study group:
Piero Luigi Almasio, Giovanni Battista Gaeta, Evangelista Sagnelli, Tommaso Stroffolini, Angelo Andriulli, Sergio Babudieri⁹, Giuseppina Brancaccio, Bruno Cacopardo¹⁰, Guido Colloredo, Nicola Coppola², Massimo De Luca¹¹, Caterina Furlan, Anna Licata¹², Filomena Morisco, Mario Pirisi, Mariantonietta Pisaturo¹³, Floriano Rosina¹⁴, Maurizio Russello¹⁵, Caterina Sagnelli, Teresa Santantonio¹⁶, Antonina Smedile¹⁷

Affiliations

¹ Department of Tropical and Infectious Diseases, Policlinico Umberto Primo, Rome, Italy.
² Department of Mental Health and Public Medicine, Second University of Naples, Italy.
³ Infectious Diseases, Department of Mental and Physical Health and Preventive Medicine, Second University of Naples, Italy.
⁴ Gastroenterology Unit, Fondazione "Casa Sollievo della Sofferenza" IRCCS Hospital, San Giovanni Rotondo, Foggia, Italy.
⁵ Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy.
⁶ Department of Internal Medicine, San Pietro Hospital, Ponte San Pietro, Italy.
⁷ Department of Clinical Medicine and Surgery, Gastroenterology Unit, University of Naples "Federico II", Naples, Italy.
⁸ Gastroenterology & Hepatology Unit, Di. Bi.MI. S., University of Palermo, Italy. Electronic address: piero.almasio@unipa.it.
⁹ Clinical of Infectious Disease, University of Sassari, 07100 Sassari, Italy.
¹⁰ Infectious Diseases, University of Catania, Italy.
¹¹ Liver Unit, Department of Transplantation, Division of Hepatology, Cardarelli Hospital, Italy.
¹² Gastroenterology & Hepatology Unit, Di. Bi.MI. S., University of Palermo, Italy.
¹³ Division of Infectious Diseases, AORN Sant'Anna e San Sebastiano di Caserta, 81100 Caserta, Italy.
¹⁴ Hepatogastroenterology Division, Ospedale Gradenigo, 10153 Torino, Italy.
¹⁵ Liver Unit, Hospital "G. Garibaldi" Catania, Catania, Italy.
¹⁶ Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy.
¹⁷ Department of Gastroenterology, Molinette Hospital, C.so Bramante 88, 10126 Turin, Italy.

PMID: 27836249
DOI: 10.1016/j.ejim.2016.10.012

Abstract

Background: Previous cross-sectional studies have shown that hepatitis C virus (HCV) infection had been the main agent associated with liver cirrhosis in Italy.

Aim: To assess epidemiological, laboratory and clinical features of liver cirrhosis in Italy in 2014.

Patients: Out of the 2557 consecutive subjects evaluated in 16 hospitals located throughout Italy in 2014, 832 (32.6%) had liver cirrhosis and were enrolled in this study.

Results: The mean age of subjects was 60.3years, with a male/female ratio of 1.7; 74.9% of cases had Child A cirrhosis and 17.9% superimposed hepatocellular carcinoma. HCV infection, alone or in combination with other aetiologic agents, was responsible of 58.6% of cases, HBV aetiology accounted for the 17.6% and alcohol abuse for the 16.0%. Compared with virus-related cirrhotic patients, those alcohol-related more frequently showed decompensation (p=0.02).

Conclusions: Compared to previous surveys performed in 1992 and in 2001, we observe a statistically significant (p<0.05) decreasing role of both HCV infection and alcohol abuse as aetiologic agents of liver cirrhosis in Italy, explaining, at least in part, the slow, progressive decline of the mortality rate for liver cirrhosis in the last decades in this country (from 34.5 deaths/100,000 inhabitants in1980 to 10.8 in 2012).

Keywords: Alcohol abuse; HBV; HCV; Liver cirrhosis; Liver cirrhosis epidemiology.

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Characteristics of liver cirrhosis in Italy: Evidence for a decreasing role of HCV aetiology

Collaborators

Affiliations

Characteristics of liver cirrhosis in Italy: Evidence for a decreasing role of HCV aetiology

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