Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Feb 7;8(6):10637-10649.
doi: 10.18632/oncotarget.12885.

The changing characteristics and molecular profiles of papillary thyroid carcinoma over time: a systematic review

Huy Gia Vuong  1   2 , Ahmed M A Altibi  3 , Amr Hesham Abdelhamid  4 , Phuong Uyen Duong Ngoc  5 , Vo Duy Quan  6 , Mohamed Yousef Tantawi  7 , Mohamed Elfil  8 , Tran Le Huy Vu  9 , Ahmed Elgebaly  10 , Naoki Oishi  1 , Tadao Nakazawa  1 , Kenji Hirayama  11 , Ryohei Katoh  1 , Nguyen Tien Huy  12 , Tetsuo Kondo  1
Affiliations
Review

The changing characteristics and molecular profiles of papillary thyroid carcinoma over time: a systematic review

Huy Gia Vuong et al. Oncotarget. .

Abstract

Background: The genetic alterations of papillary thyroid carcinoma (PTC) have been reported to change over the past few decades. We performed this systematic review to further examine the trends and modifications of patient demographic, clinicopathological features and molecular profiles of PTC over time.

Methods: A literature search was performed within six electronic databases to identify relevant articles. The inclusion criteria were published studies investigating BRAF mutations, RET/PTC rearrangements or RAS mutations in PTCs or classical PTCs. Two teams of reviewers independently screened titles and abstracts of all articles. Full texts of potential articles were read and extracted data were listed and stratified into an excel file according to country, city, institution, and surgical time period. Student t test and Pearson Chi-square were used to analyze the trends of demographic and clinicopathological features of PTC patients and the prevalence of each genetic alteration in individual institutions.

Results: From 3139 articles, we included 16 articles for final analysis. Our results showed an increasing trend of BRAF and a decreasing trend of RET/PTC prevalence over time in PTCs and classical PTCs, accompanied by an older age of PTC patients, an increase in proportion of PTMC and less aggressive behaviours of tumours.

Conclusions: The demographic and clinicopathological characteristics and molecular profile of PTCs have been changing over the past few decades. These modifications suggest changes in etiologies and risk factors of thyroid cancer that influence the tumorigenesis of PTCs.

Keywords: BRAF; RAS; RET/PTC; papillary; thyroid carcinoma.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST

All authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1. Flow diagram of study selection
Abbreviations: WHO GHL, World Health Organization Global Health Library; VHL, Virtual Health Library.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Kondo T, Ezzat S, Asa SL. Pathogenetic mechanisms in thyroid follicular-cell neoplasia. Nat Rev Cancer. 2006;6:292–306. doi: 10.1038/nrc1836. - DOI - PubMed
    1. Kilfoy BA, Zheng T, Holford TR, Han X, Ward MH, Sjodin A, Zhang Y, Bai Y, Zhu C, Guo GL, Rothman N, Zhang Y. International patterns and trends in thyroid cancer incidence, 1973-2002. Cancer Causes Control. 2009;20:525–31. doi: 10.1007/s10552-008-9260-4. - DOI - PMC - PubMed
    1. Davies L, Welch HG. Increasing incidence of thyroid cancer in the United States, 1973-2002. JAMA. 2006;295:2164–7. doi: 10.1001/jama.295.18.2164. - DOI - PubMed
    1. Davies L, Welch HG. Current thyroid cancer trends in the United States. JAMA Otolaryngol Head Neck Surg. 2014;140:317–22. doi: 10.1001/jamaoto.2014.1. - DOI - PubMed
    1. Chou A, Fraser S, Toon CW, Clarkson A, Sioson L, Farzin M, Cussigh C, Aniss A, O’Neill C, Watson N, Clifton-Bligh RJ, Learoyd DL, Robinson BG, et al. A Detailed Clinicopathologic Study of ALK-translocated Papillary Thyroid Carcinoma. Am J Surg Pathol. 2015;39:652–9. doi: 10.1097/PAS.0000000000000368. - DOI - PMC - PubMed

MeSH terms