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Review
. 2016 Nov 17;23(11):1325-1333.
doi: 10.1016/j.chembiol.2016.09.011. Epub 2016 Oct 20.

RNA-DNA Triplex Formation by Long Noncoding RNAs

Yue Li  1 , Junetha Syed  1 , Hiroshi Sugiyama  2
Affiliations
Free article
Review

RNA-DNA Triplex Formation by Long Noncoding RNAs

Yue Li et al. Cell Chem Biol. .
Free article

Abstract

Long noncoding RNAs (lncRNAs) play a pivotal role in the regulation of biological processes through various mechanisms that are not fully understood. Proposed mechanisms include regulation based on RNA-protein interactions, as well as RNA-RNA interactions and RNA-DNA interactions. Here, we focus on one possible mechanism that lncRNA might be using to impact biological function, the RNA-DNA triplex formation. We summarize currently available examples of lncRNA triplex formation and discuss the details surrounding orientation of triplex formation as one of the key properties guiding this process. We propose that symmetrical triplex-forming motifs, especially those in cis-acting lncRNAs, favor triplex formation. We also consider the effects of lncRNA structures, protein or ligand binding, and chromatin structures on the lncRNAs triplex formation.

Keywords: long noncoding RNA; mechanism; symmetric motif; triplex.

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