Molecular Evolution of Human Coronavirus Genomes
- PMID: 27743750
- PMCID: PMC7111218
- DOI: 10.1016/j.tim.2016.09.001
Molecular Evolution of Human Coronavirus Genomes
Abstract
Human coronaviruses (HCoVs), including SARS-CoV and MERS-CoV, are zoonotic pathogens that originated in wild animals. HCoVs have large genomes that encode a fixed array of structural and nonstructural components, as well as a variety of accessory proteins that differ in number and sequence even among closely related CoVs. Thus, in addition to recombination and mutation, HCoV genomes evolve through gene gains and losses. In this review we summarize recent findings on the molecular evolution of HCoV genomes, with special attention to recombination and adaptive events that generated new viral species and contributed to host shifts and to HCoV emergence. VIDEO ABSTRACT.
Keywords: gene gain/loss; host shift; human coronavirus; molecular evolution; positive selection; recombination.
Copyright © 2016 Elsevier Ltd. All rights reserved.
Figures
Similar articles
-
Rampant C→U Hypermutation in the Genomes of SARS-CoV-2 and Other Coronaviruses: Causes and Consequences for Their Short- and Long-Term Evolutionary Trajectories.mSphere. 2020 Jun 24;5(3):e00408-20. doi: 10.1128/mSphere.00408-20. mSphere. 2020. PMID: 32581081 Free PMC article.
-
A comparative recombination analysis of human coronaviruses and implications for the SARS-CoV-2 pandemic.Sci Rep. 2021 Aug 30;11(1):17365. doi: 10.1038/s41598-021-96626-8. Sci Rep. 2021. PMID: 34462471 Free PMC article.
-
Zoonotic origins of human coronaviruses.Int J Biol Sci. 2020 Mar 15;16(10):1686-1697. doi: 10.7150/ijbs.45472. eCollection 2020. Int J Biol Sci. 2020. PMID: 32226286 Free PMC article. Review.
-
Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination.J Virol. 2015 Oct;89(20):10532-47. doi: 10.1128/JVI.01048-15. Epub 2015 Aug 12. J Virol. 2015. PMID: 26269185 Free PMC article.
-
Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses.Trends Microbiol. 2016 Jun;24(6):490-502. doi: 10.1016/j.tim.2016.03.003. Epub 2016 Mar 21. Trends Microbiol. 2016. PMID: 27012512 Free PMC article. Review.
Cited by
-
High transmission of endemic human coronaviruses before and during the COVID-19 pandemic in adolescents in Cebu, Philippines.BMC Infect Dis. 2024 Sep 27;24(1):1042. doi: 10.1186/s12879-024-09672-8. BMC Infect Dis. 2024. PMID: 39333882
-
Intra- and inter-host origin, evolution dynamics and spatial-temporal transmission characteristics of circoviruses.Front Immunol. 2024 Aug 2;15:1332444. doi: 10.3389/fimmu.2024.1332444. eCollection 2024. Front Immunol. 2024. PMID: 39156896 Free PMC article.
-
Potential Transcriptional Enhancers in Coronaviruses: From Infectious Bronchitis Virus to SARS-CoV-2.Int J Mol Sci. 2024 Jul 23;25(15):8012. doi: 10.3390/ijms25158012. Int J Mol Sci. 2024. PMID: 39125583 Free PMC article.
-
Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques.bioRxiv [Preprint]. 2024 Jul 30:2024.07.30.605768. doi: 10.1101/2024.07.30.605768. bioRxiv. 2024. PMID: 39109178 Free PMC article. Preprint.
-
Identification and Characterization of an Alphacoronavirus in Rhinolophus sinicus and a Betacoronavirus in Apodemus ilex in Yunnan, China.Microorganisms. 2024 Jul 21;12(7):1490. doi: 10.3390/microorganisms12071490. Microorganisms. 2024. PMID: 39065258 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous