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. 1978 Jun:3:302-6.

Definitive evidence for hypoxic cells influencing cure in cancer therapy

R S Bush, R D Jenkin, W E Allt, F A Beale, H Bean, A J Dembo, J F Pringle

Definitive evidence for hypoxic cells influencing cure in cancer therapy

R S Bush et al. Br J Cancer Suppl. 1978 Jun.

Abstract

From an analysis of 2803 patients with carcinoma of the cervix treated by radiation therapy, a 62% cure rate can be shown. In those patients with Stage IIb and III disease, a haemoglobin level during treatment of below 12 g% was associated with a significantly higher pelvic recurrence rate, and also lower cure rate, than for those with a haemoglobin level 12g% or more. A prospective study shows that the correction of anaemia is associated with a decreased pelvic recurrence rate and an increased cure rate consistent with tumour hypoxia being greater in anaemic patients than in those with a normal haemoglobin level. It is also consistent with the thesis that hypoxia controls the radiation local control rate in patients with advanced carcinoma of the cervix.

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