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Review
. 2017 Feb;27(2):151-162.
doi: 10.1016/j.tcb.2016.08.011. Epub 2016 Sep 16.

Disassembly of the Dying: Mechanisms and Functions

Georgia K Atkin-Smith  1 , Ivan K H Poon  2
Affiliations
Review

Disassembly of the Dying: Mechanisms and Functions

Georgia K Atkin-Smith et al. Trends Cell Biol. 2017 Feb.

Abstract

The disassembly of an apoptotic cell into subcellular fragments, termed apoptotic bodies (ApoBDs), is a hallmark of apoptosis. Although the generation of ApoBDs is generally understood as being stochastic, it is becoming increasingly clear that ApoBD formation is a highly regulated process involving distinct morphological steps and molecular factors. Functionally, ApoBDs could facilitate the efficient clearance of apoptotic material by surrounding phagocytes as well as mediate the transfer of biomolecules including microRNAs and proteins between cells to aid in intercellular communications. Therefore, the formation of ApoBDs is an important process downstream from apoptotic cell death. We discuss here the mechanisms and functions of apoptotic cell disassembly.

Keywords: apoptosis; apoptotic bodies; cell clearance.

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