Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks - Implications for coronavirus vaccine development

doi:10.1080/21645515.2016.1228500

. 2017 Jan 2;13(1):186-189.

doi: 10.1080/21645515.2016.1228500. Epub 2016 Sep 20.

Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks - Implications for coronavirus vaccine development

Oi-Wing Ng¹, Yee-Joo Tan^{1

2}

Affiliations

¹ a Department of Microbiology and Immunology , Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore , Singapore.
² b Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research) , Singapore.

PMID: 27644155
PMCID: PMC5287300
DOI: 10.1080/21645515.2016.1228500

Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks - Implications for coronavirus vaccine development

Oi-Wing Ng et al. Hum Vaccin Immunother. 2017.

. 2017 Jan 2;13(1):186-189.

doi: 10.1080/21645515.2016.1228500. Epub 2016 Sep 20.

Authors

Oi-Wing Ng¹, Yee-Joo Tan^{1

2}

Affiliations

¹ a Department of Microbiology and Immunology , Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore , Singapore.
² b Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research) , Singapore.

PMID: 27644155
PMCID: PMC5287300
DOI: 10.1080/21645515.2016.1228500

Abstract

The severe acute respiratory syndrome coronavirus (SARS-CoV) first emerged in 2003, causing the SARS epidemic which resulted in a 10% fatality rate. The advancements in metagenomic techniques have allowed the identification of SARS-like coronaviruses (SL-CoVs) sequences that share high homology to the human SARS-CoV epidemic strains from wildlife bats, presenting concrete evidence that bats are the origin and natural reservoir of SARS-CoV. The application of reverse genetics further enabled that characterization of these bat CoVs and the prediction of their potential to cause disease in humans. The knowledge gained from such studies is valuable in the surveillance and preparation of a possible future outbreak caused by a spill-over of these bat SL-CoVs.

Keywords: Bats; Emerging and re-emerging virus; SARS-like coronavirus; Severe acute respiratory syndrome coronavirus; Zoonotic virus.

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[1] Peiris JS, Guan Y, Yuen KY. Severe acute respiratory syndrome. Nat Med 2004; 10:S88-97; PMID:15577937; http://dx.doi.org/10.1038/nm1143 - DOI - PMC - PubMed

[2] Peiris JS, Guan Y, Yuen KY. Severe acute respiratory syndrome. Nat Med 2004; 10:S88-97; PMID:15577937; http://dx.doi.org/10.1038/nm1143 - DOI - PMC - PubMed

[3] Guan Y, Zheng BJ, He YQ, Liu XL, Zhuang ZX, Cheung CL, et al.. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science (New York, NY) 2003; 302:276-8; http://dx.doi.org/10.1126/science.1087139 - DOI - PubMed

[4] Guan Y, Zheng BJ, He YQ, Liu XL, Zhuang ZX, Cheung CL, et al.. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science (New York, NY) 2003; 302:276-8; http://dx.doi.org/10.1126/science.1087139 - DOI - PubMed

[5] Kan B, Wang M, Jing H, Xu H, Jiang X, Yan M, et al.. Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms. J Virol 2005; 79:11892-900; PMID:16140765; http://dx.doi.org/10.1128/JVI.79.18.11892-11900.2005 - DOI - PMC - PubMed

[6] Kan B, Wang M, Jing H, Xu H, Jiang X, Yan M, et al.. Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms. J Virol 2005; 79:11892-900; PMID:16140765; http://dx.doi.org/10.1128/JVI.79.18.11892-11900.2005 - DOI - PMC - PubMed

[7] Song HD, Tu CC, Zhang GW, Wang SY, Zheng K, Lei LC, Chen QX, Gao YW, Zhou HQ, Xiang H, et al.. Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proc Natl Acad Sci U S A 2005; 102:2430-5; PMID:15695582; http://dx.doi.org/10.1073/pnas.0409608102 - DOI - PMC - PubMed

[8] Song HD, Tu CC, Zhang GW, Wang SY, Zheng K, Lei LC, Chen QX, Gao YW, Zhou HQ, Xiang H, et al.. Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proc Natl Acad Sci U S A 2005; 102:2430-5; PMID:15695582; http://dx.doi.org/10.1073/pnas.0409608102 - DOI - PMC - PubMed

[9] Mokili JL, Rohwer F, Dutilh BE. Metagenomics and future perspectives in virus discovery. Curr Opin Virol 2012; 2:63-77; PMID:22440968; http://dx.doi.org/10.1016/j.coviro.2011.12.004 - DOI - PMC - PubMed

[10] Mokili JL, Rohwer F, Dutilh BE. Metagenomics and future perspectives in virus discovery. Curr Opin Virol 2012; 2:63-77; PMID:22440968; http://dx.doi.org/10.1016/j.coviro.2011.12.004 - DOI - PMC - PubMed

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Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks - Implications for coronavirus vaccine development

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Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks - Implications for coronavirus vaccine development

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