The Effects of Influenza Vaccination during Pregnancy on Birth Outcomes: A Systematic Review and Meta-Analysis
- PMID: 27603545
- DOI: 10.1055/s-0036-1586101
The Effects of Influenza Vaccination during Pregnancy on Birth Outcomes: A Systematic Review and Meta-Analysis
Abstract
Objective Numerous observational studies have evaluated the relationship between influenza vaccination during pregnancy and birth outcomes. The number of studies on this subject has increased, especially after the 2009 A/H1N1 pandemic (A/H1N1pdm09). This meta-analysis aims to determine the impact of maternal vaccination with either seasonal trivalent inactivated influenza vaccines (IIV) or A/H1N1pdm09 monovalent vaccines on the rates of preterm (PTB), small for gestational age (SGA), and low birth weight (LBW) births. Methods English language randomized controlled trials and observational studies assessing the proposed outcomes after administration of influenza vaccine during pregnancy were screened. Observational studies were included if they presented adjusted measures and if the total number of women evaluated reached predefined thresholds. Sensitivity analyses were performed, including all published observational studies irrespectively of the sample size. Results A total of 5 and 13 publications that assessed the impact of IIV and monovalent A/H1N1pdm09 vaccines, respectively, fulfilled the inclusion criteria for the main analyses. The rate of PTB and LBW was lower in women who received IIV during pregnancy compared with nonvaccinated women (odds ratio [OR]: 0.87; 95% confidence interval [CI]: 0.77, 0.98 for PTB and OR: 0.74; 95% CI: 0.61, 0.88 for LBW); and in women vaccinated with monovalent A/H1N1pdm09 versus nonvaccinated women (OR: 0.92; 95% CI: 0.85, 0.99 for PTB and OR: 0.88; 95% CI: 0.79, 0.98 for LBW). No significant impact of vaccination on SGA birth rates was detected in the main analyses independently of the vaccine group. Conclusion Receipt of influenza vaccine during pregnancy was associated with a decreased risk of PTB and LBW.
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Similar articles
-
Risk of Preterm or Small-for-Gestational-Age Birth After Influenza Vaccination During Pregnancy: Caveats When Conducting Retrospective Observational Studies.Am J Epidemiol. 2016 Aug 1;184(3):176-86. doi: 10.1093/aje/kww043. Epub 2016 Jul 22. Am J Epidemiol. 2016. PMID: 27449414 Free PMC article.
-
Neonatal outcomes after antenatal influenza immunization during the 2009 H1N1 influenza pandemic: impact on preterm birth, birth weight, and small for gestational age birth.Clin Infect Dis. 2013 May;56(9):1216-22. doi: 10.1093/cid/cit045. Epub 2013 Feb 1. Clin Infect Dis. 2013. PMID: 23378281 Free PMC article.
-
The safety of inactivated influenza vaccines in pregnancy for birth outcomes: a systematic review.Hum Vaccin Immunother. 2019;15(3):687-699. doi: 10.1080/21645515.2018.1540807. Epub 2018 Nov 15. Hum Vaccin Immunother. 2019. PMID: 30380986 Free PMC article.
-
Fetal death and preterm birth associated with maternal influenza vaccination: systematic review.BJOG. 2015 Jan;122(1):17-26. doi: 10.1111/1471-0528.12977. Epub 2014 Jul 10. BJOG. 2015. PMID: 25040307 Review.
-
Review on the effects of influenza vaccination during pregnancy on preterm births.Hum Vaccin Immunother. 2015;11(11):2538-48. doi: 10.1080/21645515.2015.1059976. Epub 2015 Aug 12. Hum Vaccin Immunother. 2015. PMID: 26267701 Free PMC article. Review.
Cited by
-
Safety of COVID-19 vaccines during pregnancy: A systematic review and meta-analysis.Vaccine. 2023 Jun 7;41(25):3688-3700. doi: 10.1016/j.vaccine.2023.03.038. Epub 2023 Mar 27. Vaccine. 2023. PMID: 37012114 Free PMC article. Review.
-
Association between maternal influenza vaccination and neurodevelopmental disorders in childhood: a longitudinal, population-based linked cohort study.Arch Dis Child. 2023 Aug;108(8):647-653. doi: 10.1136/archdischild-2022-324269. Epub 2023 Mar 31. Arch Dis Child. 2023. PMID: 37001967 Free PMC article.
-
Barriers and facilitators of vaccine hesitancy for COVID-19, influenza, and pertussis during pregnancy and in mothers of infants under two years: An umbrella review.PLoS One. 2023 Mar 2;18(3):e0282525. doi: 10.1371/journal.pone.0282525. eCollection 2023. PLoS One. 2023. PMID: 36862698 Free PMC article.
-
Maternal Vaccination and Vaccine Hesitancy.Pediatr Clin North Am. 2023 Apr;70(2):259-269. doi: 10.1016/j.pcl.2022.11.004. Pediatr Clin North Am. 2023. PMID: 36841594 Free PMC article. Review.
-
Impact of industry sponsorship on the quality of systematic reviews of vaccines: a cross-sectional analysis of studies published from 2016 to 2019.Syst Rev. 2022 Aug 22;11(1):174. doi: 10.1186/s13643-022-02051-x. Syst Rev. 2022. PMID: 35996186 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical