Extracellular vesicles swarm the cancer microenvironment: from tumor-stroma communication to drug intervention

doi:10.1038/onc.2016.253

Review

. 2017 Feb 16;36(7):877-884.

doi: 10.1038/onc.2016.253. Epub 2016 Aug 22.

Extracellular vesicles swarm the cancer microenvironment: from tumor-stroma communication to drug intervention

F Wendler¹, R Favicchio², T Simon¹, C Alifrangis³, J Stebbing², G Giamas¹

Affiliations

¹ School of Life Sciences, Department of Biochemistry and Biomedicine, University of Sussex, Brighton, UK.
² Imperial College London, Department of Surgery and Cancer, Division of Cancer, London, UK.
³ Imperial College London, Department of Medical Oncology, NHS Trust, Hammersmith Hospital, London, UK.

PMID: 27546617
DOI: 10.1038/onc.2016.253

Review

Extracellular vesicles swarm the cancer microenvironment: from tumor-stroma communication to drug intervention

F Wendler et al. Oncogene. 2017.

. 2017 Feb 16;36(7):877-884.

doi: 10.1038/onc.2016.253. Epub 2016 Aug 22.

Authors

F Wendler¹, R Favicchio², T Simon¹, C Alifrangis³, J Stebbing², G Giamas¹

Affiliations

¹ School of Life Sciences, Department of Biochemistry and Biomedicine, University of Sussex, Brighton, UK.
² Imperial College London, Department of Surgery and Cancer, Division of Cancer, London, UK.
³ Imperial College London, Department of Medical Oncology, NHS Trust, Hammersmith Hospital, London, UK.

PMID: 27546617
DOI: 10.1038/onc.2016.253

Abstract

Intercellular communication sets the pace for transformed cells to survive and to thrive. Extracellular vesicles (EVs), such as exosomes, microvesicles and large oncosomes, are involved in this process shuttling reciprocal signals and other molecules between transformed and stromal cells, including fibroblasts, endothelial and immune cells. As a result, these cells are adapted or recruited to a constantly evolving cancer microenvironment. Moreover, EVs take part in the response to anticancer therapeutics not least by promoting drug resistance throughout the targeted tumor. Finally, circulating EVs can also transport important molecules to remote destinations in order to prime metastatic niches in an otherwise healthy tissue. Although the understanding of EV biology remains a major challenge in the field, their characteristics create new opportunities for advances in cancer diagnostics and therapeutics.

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References

1. Oncoscience. 2014 Mar 16;1(2):132-57 - PubMed
1. Oncogene. 2014 Sep 11;33(37):4613-22 - PubMed
1. Mol Cell. 2010 Jul 9;39(1):133-44 - PubMed
1. Cell. 2012 Dec 21;151(7):1542-56 - PubMed
1. Nature. 2016 Mar 3;531(7592):110-3 - PubMed

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[1] Oncoscience. 2014 Mar 16;1(2):132-57 - PubMed

[2] Oncoscience. 2014 Mar 16;1(2):132-57 - PubMed

[3] Oncogene. 2014 Sep 11;33(37):4613-22 - PubMed

[4] Oncogene. 2014 Sep 11;33(37):4613-22 - PubMed

[5] Mol Cell. 2010 Jul 9;39(1):133-44 - PubMed

[6] Mol Cell. 2010 Jul 9;39(1):133-44 - PubMed

[7] Cell. 2012 Dec 21;151(7):1542-56 - PubMed

[8] Cell. 2012 Dec 21;151(7):1542-56 - PubMed

[9] Nature. 2016 Mar 3;531(7592):110-3 - PubMed

[10] Nature. 2016 Mar 3;531(7592):110-3 - PubMed

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Extracellular vesicles swarm the cancer microenvironment: from tumor-stroma communication to drug intervention

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Extracellular vesicles swarm the cancer microenvironment: from tumor-stroma communication to drug intervention

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