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. 2016 Sep 15:368:19-24.
doi: 10.1016/j.jns.2016.06.046. Epub 2016 Jun 22.

MicroRNAs-424 and 206 are potential prognostic markers in spinal onset amyotrophic lateral sclerosis

Helen M T de Andrade  1 , Milena de Albuquerque  1 , Simoni H Avansini  2 , Cristiane de S Rocha  2 , Danyella B Dogini  2 , Anamarli Nucci  1 , Benilton Carvalho  2 , Iscia Lopes-Cendes  2 , Marcondes C França Jr  3
Affiliations

MicroRNAs-424 and 206 are potential prognostic markers in spinal onset amyotrophic lateral sclerosis

Helen M T de Andrade et al. J Neurol Sci. .

Abstract

Introduction: Skeletal muscle microRNAs (miRNAs) are potential candidate biomarkers for amyotrophic lateral sclerosis (ALS) that deserve further investigation.

Objectives: To identify miRNAs abnormally expressed in the skeletal muscle and plasma of patients with ALS, and to correlate them with parameters of disease progression.

Methods: Expression profile of miRNAs in muscle was evaluated using an array platform. Subsequently we assessed the plasmatic expression of candidate miRNAs in a set of 39 patients/39 controls. We employed generalized estimating equations to investigate correlations with clinical data.

Results: We identified 11 miRNAs differentially expressed in the muscle of ALS patients; of these, miR424, miR-214 and miR-206 were validated by qPCR in muscle samples. In plasma, we found only miR-424 and miR 206 to be overexpressed. Baseline expression of miR-424 and 206 correlated with clinical deterioration over time.

Conclusion: MiR-424 and miR-206 are potential prognostic markers for ALS.

Keywords: Amyotrophic lateral sclerosis; MicroRNA; Motor neuron; Prognosis; Skeletal muscle.

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