The Future of Precision Medicine in Oncology
- PMID: 27514468
- DOI: 10.1016/j.cll.2016.05.003
The Future of Precision Medicine in Oncology
Abstract
Precision medicine in oncology focuses on identifying which therapies are most effective for each patient based on genetic characterization of the cancer. Traditional chemotherapy is cytotoxic and destroys all cells that are rapidly dividing. The foundation of precision medicine is targeted therapies and selecting patients who will benefit most from these therapies. One of the newest aspects of precision medicine is liquid biopsy. A liquid biopsy includes analysis of circulating tumor cells, cell-free nucleic acid, or exosomes obtained from a peripheral blood draw. These can be studied individually or in combination and collected serially, providing real-time information as a patient's cancer changes.
Keywords: Cell-free nucleic acid (cfNA); Circulating tumor cell (CTC); Exosomes; Extracellular vesicle (EV); Liquid biopsy; Targeted therapy.
Copyright © 2016 Elsevier Inc. All rights reserved.
Similar articles
-
Application of liquid biopsy in precision medicine: opportunities and challenges.Front Med. 2017 Dec;11(4):522-527. doi: 10.1007/s11684-017-0526-7. Epub 2017 Jul 25. Front Med. 2017. PMID: 28744793 Review.
-
Liquid Biopsy: From Basic Research to Clinical Practice.Adv Clin Chem. 2018;83:73-119. doi: 10.1016/bs.acc.2017.10.003. Epub 2017 Nov 23. Adv Clin Chem. 2018. PMID: 29304904 Review.
-
Liquid Biopsy: Current Status and Future Perspectives.Oncol Res Treat. 2017;40(7-8):404-408. doi: 10.1159/000478018. Epub 2017 Jul 13. Oncol Res Treat. 2017. PMID: 28693023 Review.
-
Promises and Pitfalls of Using Liquid Biopsy for Precision Medicine.Cancer Res. 2019 Jun 1;79(11):2798-2804. doi: 10.1158/0008-5472.CAN-18-3402. Epub 2019 May 20. Cancer Res. 2019. PMID: 31109952 Review.
-
Perspective on Precision Medicine in Oncology.Pharmacotherapy. 2017 Sep;37(9):988-989. doi: 10.1002/phar.1975. Epub 2017 Aug 7. Pharmacotherapy. 2017. PMID: 28632968 Free PMC article. Review.
Cited by
-
Combining the amplification refractory mutation system and high-resolution melting analysis for KRAS mutation detection in clinical samples.Anal Bioanal Chem. 2023 Jun;415(14):2849-2863. doi: 10.1007/s00216-023-04696-6. Epub 2023 Apr 25. Anal Bioanal Chem. 2023. PMID: 37097304 Free PMC article.
-
Prognositic significance of P-cadherin expression in breast cancer: Protocol for a meta-analysis.Medicine (Baltimore). 2019 Mar;98(12):e14924. doi: 10.1097/MD.0000000000014924. Medicine (Baltimore). 2019. PMID: 30896652 Free PMC article.
-
Polyacrylamide/Phytic Acid/Polydopamine Hydrogel as an Efficient Substrate for Electrochemical Enrichment of Circulating Cell-Free DNA from Blood Plasma.ACS Omega. 2020 Mar 4;5(10):5365-5371. doi: 10.1021/acsomega.9b04397. eCollection 2020 Mar 17. ACS Omega. 2020. PMID: 32201826 Free PMC article.
-
Blood-based systems biology biomarkers for next-generation clinical trials in Alzheimer's disease .Dialogues Clin Neurosci. 2019;21(2):177-191. doi: 10.31887/DCNS.2019.21.2/hhampel. Dialogues Clin Neurosci. 2019. PMID: 31636492 Free PMC article.
-
Assessment of stromal SCD-induced drug resistance of PDAC using 3D-printed zPDX model chips.iScience. 2022 Dec 5;26(1):105723. doi: 10.1016/j.isci.2022.105723. eCollection 2023 Jan 20. iScience. 2022. PMID: 36590169 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources