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. 2016 Oct;43(10):1157-63.
doi: 10.1007/s11033-016-4051-6. Epub 2016 Aug 6.

Minocycline ameliorates D-galactose-induced memory deficits and loss of Arc/Arg3.1 expression

Xu Li  1 , Fen Lu  2 , Wei Li  3 , Jun Xu  3 , Xiao-Jing Sun  3 , Ling-Zhi Qin  3 , Qian-Lin Zhang  3 , Yong Yao  3 , Qing-Kai Yu  4 , Xin-Liang Liang  3
Affiliations

Minocycline ameliorates D-galactose-induced memory deficits and loss of Arc/Arg3.1 expression

Xu Li et al. Mol Biol Rep. 2016 Oct.

Abstract

Dysfunction of learning and memory is widely found in many neurological diseases. Understanding how to preserve the normal function of learning and memory will be extremely beneficial for the treatment of these diseases. However, the possible protective effect of minocycline in memory impairment is unknown. We used the well-established D-galactose rat amnesia model and two behavioral tasks, the Morris water maze and the step-down task, for memory evaluation. Western blot and PCR were used to examine the protein and mRNA levels of Arc/Arg3.1. We report that minocycline supplementation ameliorates both the spatial and fear memory deficits caused by D-galactose. We also found that Arc/Arg3.1, c-fos, and brain-derived neurotrophic factor levels are decreased in the D-galactose animal model, and that minocycline reverses the protein and mRNA levels of Arc in the hippocampus, suggesting the potential role of Arc/Arg3.1 in minocycline's neuroprotective mechanism. Our study strongly suggests that minocycline can be used as a novel treatment for memory impairment in neurological diseases.

Keywords: Arc; D-Galactose; Memory deficits.

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