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. 2017 Jan;69(1):320-325.
doi: 10.1016/j.jjcc.2016.06.011. Epub 2016 Aug 3.

High levels of stromal cell-derived factor-1α predict secondary cardiac events in stable patients with a history of myocardial infarction

Satoshi Matsuoka  1 , Manabu Uematsu  1 , Takamitsu Nakamura  1 , Takuya Shimizu  1 , Mika Futamata  1 , Jun-Ei Obata  1 , Daisuke Fujioka  1 , Kazuto Nakamura  1 , Toru Yoshizaki  1 , Kiyotaka Kugiyama  2
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Free article

High levels of stromal cell-derived factor-1α predict secondary cardiac events in stable patients with a history of myocardial infarction

Satoshi Matsuoka et al. J Cardiol. 2017 Jan.
Free article

Abstract

Background: We recently showed that stromal cell-derived factor (SDF)-1α, a pro-inflammatory mediator, is produced in infarcted myocardium and is associated with left ventricular (LV) adverse remodeling and progressive dysfunction following acute myocardial infarction (AMI). The current study examined whether SDF-1α levels in the peripheral vein can provide prognostic information of outcomes in stable patients with a history of MI.

Methods: Plasma levels of SDF-1α in the peripheral vein were measured by enzyme-linked immunosorbent assay in 192 stable patients with a history of MI. All patients were followed prospectively for a period of 90 months or until occurrence of one of the following cardiac events: cardiac death, non-fatal myocardial infarction, unstable angina requiring unplanned coronary revascularization, or worsening heart failure requiring hospital admission.

Results: During the follow-up period (77±26 months), 30 patients had cardiac events. Multivariate Cox analysis revealed that high levels of SDF-1α (≥2162pg/mL; a cut-off value determined by receiver-operating characteristic analysis) were a significant predictor of cardiac events, independent of traditional risk factors (HR: 1.98; 95% CI: 1.38-2.85; p<0.001). The addition of high levels of SDF-1α to conventional risk factors including brain natriuretic peptide improved net reclassification improvement (NRI) and integrated discrimination improvement (IDI) (NRI 0.90, p<0.0001; and IDI 0.05, p=0.002).

Conclusions: High levels of SDF-1α predicted secondary cardiac events in stable patients with a history of MI. SDF-1α levels may be a useful risk assessment tool in patients with a history of MI.

Keywords: Cardiac events; Inflammatory marker; Myocardial infarction; Prognosis; Stromal cell-derived factor-1α.

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