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. 2016 Nov 1;2(11):1403-1404.
doi: 10.1001/jamaoncol.2016.2450.

Classification of Advanced Human Cancers Based on Tumor Immunity in the MicroEnvironment (TIME) for Cancer Immunotherapy

Affiliations

Classification of Advanced Human Cancers Based on Tumor Immunity in the MicroEnvironment (TIME) for Cancer Immunotherapy

Yu Zhang et al. JAMA Oncol. .

Erratum in

  • Error in Figure.
    [No authors listed] [No authors listed] JAMA Oncol. 2016 Nov 1;2(11):1511. doi: 10.1001/jamaoncol.2016.5130. JAMA Oncol. 2016. PMID: 27737439 No abstract available.
No abstract available

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Chen is a consultant and/or advisory board member of and receives consulting fees from MedImmune, NextCure, and Pfizer. Dr Chen also receives patent and/or licensing payments from Bristol-Myers Squibb and Ventana, and currently has sponsored research grants from Boehringer Ingelheim, Pfizer, and NextCure. No other disclosures are reported.

Figures

Figure
Figure. Tumor Immunity in MicroEnvironment (TIME) Classification
B7-H1 indicates B7 homolog 1; IFN, interferon; MHC indicates major histocompatibility complex; PD-1, programmed cell death 1; T1–T4, tumor subtypes; TIL, tumor-infiltrating lymphocyte.

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References

    1. Lipson EJ, Forde PM, Hammers HJ, Emens LA, Taube JM, Topalian SL. Antagonists of PD-1 and PD-L1 in cancer treatment. Semin Oncol. 2015;42(4):587–600. - PMC - PubMed
    1. Tumeh PC, Harview CL, Yearley JH, et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature. 2014;515(7528):568–571. - PMC - PubMed
    1. Sanmamed MF, Chen L. Inducible expression of B7-H1 (PD-L1) and its selective role in tumor site immune modulation. Cancer J. 2014;20(4):256–261. - PMC - PubMed
    1. Taube JM, Anders RA, Young GD, et al. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med. 2012;4(127):127ra37. - PMC - PubMed
    1. Chen L, Han X. Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future. J Clin Invest. 2015;125(9):3384–3391. - PMC - PubMed