SUMO wrestles breaks to the nuclear ring's edge

doi:10.1080/15384101.2016.1216904

Editorial

. 2016 Nov 16;15(22):3011-3013.

doi: 10.1080/15384101.2016.1216904. Epub 2016 Aug 2.

SUMO wrestles breaks to the nuclear ring's edge

Chihiro Horigome¹, Susan M Gasser^{1

2}

Affiliations

¹ a Friedrich Miescher Institute for Biomedical Research , Basel , Switzerland.
² b University of Basel, Faculty of Natural Sciences , Basel , Switzerland.

PMID: 27484885
PMCID: PMC5134702
DOI: 10.1080/15384101.2016.1216904

Editorial

SUMO wrestles breaks to the nuclear ring's edge

Chihiro Horigome et al. Cell Cycle. 2016.

. 2016 Nov 16;15(22):3011-3013.

doi: 10.1080/15384101.2016.1216904. Epub 2016 Aug 2.

Authors

Chihiro Horigome¹, Susan M Gasser^{1

2}

Affiliations

¹ a Friedrich Miescher Institute for Biomedical Research , Basel , Switzerland.
² b University of Basel, Faculty of Natural Sciences , Basel , Switzerland.

PMID: 27484885
PMCID: PMC5134702
DOI: 10.1080/15384101.2016.1216904

No abstract available

Keywords: DNA damage; Mms21; Mps3; STUbL; SUMO; SUN domain protein; Siz2; Slx5/8; nuclear organization; nuclear pores.

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Figures

**Figure 1.**
The extent of SUMO chain formation affects spatial sequestration of damage and the repair pathway choice. Repair proteins bind to DSBs and eroded telomeres in yeast and become modified by Mms21 and/or Siz1/Siz2 SUMO ligases. If monoSUMOylated, the DSBs shift to Mps3 where aberrant recombination is inhibited. If Siz2 adds a polySUMO chain, it is recognized by Slx5/Slx8, a STUbL enzyme that shifts the damage to nuclear pores. At the pore, ubiquitination of the polySUMOylated substrates and proteasome degradation facilitate alternative repair pathways. Similar events happen to DSBs in heterochromatin in flies (see text).

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doi: 10.1101/gad.277665.116

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References

1. Geli V, Lisby M. Recombinational DNA repair is regulated by compartmentalization of DNA lesions at the nuclear pore complex. Bioessays 2015; 37:1287-92; PMID:26422820; http://dx.doi.org/10.1002/bies.201500084 - DOI - PubMed
1. Ptak C, Wozniak RW. Nucleoporins and chromatin metabolism. Curr Opin Cell Biol 2016; 40:153-60.; PMID:27085162; http://dx.doi.org/10.1016/j.ceb.2016.03.024 - DOI - PubMed
1. Kalousi A, Soutoglou E. Nuclear compartmentalization of DNA repair. Curr OpinGenet Dev 2016; 37:148-57.; PMID:27266837; http://dx.doi.org/10.1016/j.gde.2016.05.013 - DOI - PubMed
1. Horigome C, Oma Y, Konishi T, Schmid R, Marcomini I, Hauer MH, Dion V, Harata M, Gasser SM. SWR1 and INO80 chromatin remodelers contribute to DNA double-strand break perinuclear anchorage site choice. Mol Cell 2014; 55:626-39.; PMID:25066231; http://dx.doi.org/10.1016/j.molcel.2014.06.027 - DOI - PubMed
1. Horigome C, Bustard DE, Marcomini I, Delgoshaie N, Tsai-Pflugfelder M, Cobb JA, Gasser SM. PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL. Genes Dev 2016; 30(8):931-45 ; PMID:27056668; http://dx.doi.org/10.1101/gad.277665.116 - DOI - PMC - PubMed

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[1] Geli V, Lisby M. Recombinational DNA repair is regulated by compartmentalization of DNA lesions at the nuclear pore complex. Bioessays 2015; 37:1287-92; PMID:26422820; http://dx.doi.org/10.1002/bies.201500084 - DOI - PubMed

[2] Geli V, Lisby M. Recombinational DNA repair is regulated by compartmentalization of DNA lesions at the nuclear pore complex. Bioessays 2015; 37:1287-92; PMID:26422820; http://dx.doi.org/10.1002/bies.201500084 - DOI - PubMed

[3] Ptak C, Wozniak RW. Nucleoporins and chromatin metabolism. Curr Opin Cell Biol 2016; 40:153-60.; PMID:27085162; http://dx.doi.org/10.1016/j.ceb.2016.03.024 - DOI - PubMed

[4] Ptak C, Wozniak RW. Nucleoporins and chromatin metabolism. Curr Opin Cell Biol 2016; 40:153-60.; PMID:27085162; http://dx.doi.org/10.1016/j.ceb.2016.03.024 - DOI - PubMed

[5] Kalousi A, Soutoglou E. Nuclear compartmentalization of DNA repair. Curr OpinGenet Dev 2016; 37:148-57.; PMID:27266837; http://dx.doi.org/10.1016/j.gde.2016.05.013 - DOI - PubMed

[6] Kalousi A, Soutoglou E. Nuclear compartmentalization of DNA repair. Curr OpinGenet Dev 2016; 37:148-57.; PMID:27266837; http://dx.doi.org/10.1016/j.gde.2016.05.013 - DOI - PubMed

[7] Horigome C, Oma Y, Konishi T, Schmid R, Marcomini I, Hauer MH, Dion V, Harata M, Gasser SM. SWR1 and INO80 chromatin remodelers contribute to DNA double-strand break perinuclear anchorage site choice. Mol Cell 2014; 55:626-39.; PMID:25066231; http://dx.doi.org/10.1016/j.molcel.2014.06.027 - DOI - PubMed

[8] Horigome C, Oma Y, Konishi T, Schmid R, Marcomini I, Hauer MH, Dion V, Harata M, Gasser SM. SWR1 and INO80 chromatin remodelers contribute to DNA double-strand break perinuclear anchorage site choice. Mol Cell 2014; 55:626-39.; PMID:25066231; http://dx.doi.org/10.1016/j.molcel.2014.06.027 - DOI - PubMed

[9] Horigome C, Bustard DE, Marcomini I, Delgoshaie N, Tsai-Pflugfelder M, Cobb JA, Gasser SM. PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL. Genes Dev 2016; 30(8):931-45 ; PMID:27056668; http://dx.doi.org/10.1101/gad.277665.116 - DOI - PMC - PubMed

[10] Horigome C, Bustard DE, Marcomini I, Delgoshaie N, Tsai-Pflugfelder M, Cobb JA, Gasser SM. PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL. Genes Dev 2016; 30(8):931-45 ; PMID:27056668; http://dx.doi.org/10.1101/gad.277665.116 - DOI - PMC - PubMed

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SUMO wrestles breaks to the nuclear ring's edge

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SUMO wrestles breaks to the nuclear ring's edge

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