Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Dec 16:4:1-11.
doi: 10.2147/ITT.S49656. eCollection 2015.

Antigen-based immunotherapy for autoimmune disease: current status

Darren Lowell Hirsch  1 , Punita Ponda  1
Affiliations
Review

Antigen-based immunotherapy for autoimmune disease: current status

Darren Lowell Hirsch et al. Immunotargets Ther. .

Abstract

Autoimmune diseases are common chronic disorders that not only have a major impact on the quality of life but are also potentially life-threatening. Treatment modalities that are currently favored have conferred significant clinical benefits, but they may have considerable side effects. An optimal treatment strategy for autoimmune disease would specifically target disease-associated antigens and limit systemic side effects. Similar to allergen-specific immunotherapy for allergic rhinitis, antigen-specific immunotherapy for autoimmune disease aims to induce immune deviation and promote tolerance to specific antigens. In this review, we present the current status of studies and clinical trials in both human and animal hosts that use antigen-based immunotherapy for autoimmune disease.

Keywords: antigen; autoimmune disease; diabetes; immunotherapy; multiple sclerosis; rheumatoid arthritis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cooper GS, Bynam ML, Somers EC. Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases. J Autoimmun. 2009;33(3–4):197–207. - PMC - PubMed
    1. American Autoimmune Related Disease Association, Inc. c2004–2014. [Accessed January 17, 2014]. Available from: http://www.aarda.org/autoimmune-information/autoimmune-statistics/
    1. Lipman TH, Levitt Katz LE, Ratcliffe SJ, et al. Increasing incidence of Type 1 diabetes in youth. Diabetes Care. 2013;36(6):1597–1603. - PMC - PubMed
    1. Rosata E, Pisarri S, Salsano F. Current strategies for the treatment of autoimmune diseases. J Biol Regul Homeost Agents. 2010;24(3):251–259. - PubMed
    1. Bernatsky S, Hudson M, Suissa S. Anti-rheumatic drug use and risk of serious infections in rheumatoid arthritis. Rheumatology. 2010;46(7):1157–1160. - PubMed