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. 2016 Jul 25;14(1):65.
doi: 10.1186/s12967-016-0791-2.

Melanoma and immunotherapy bridge 2015 : Naples, Italy. 1-5 December 2015

Vashisht G. Y. Nanda  1 , Weiyi Peng  1 , Patrick Hwu  1   2 , Michael A. Davies  1 , Gennaro Ciliberto  3   4 , Luigi Fattore  3 , Debora Malpicci  5 , Luigi Aurisicchio  6 , Paolo Antonio Ascierto  3   7   8   9   4   10 , Carlo M. Croce  11 , Rita Mancini  12   13 , Stefani Spranger  14 , Thomas F. Gajewski  14   15   16   17 , Yangyang Wang  18 , Soldano Ferrone  18 , Claire Vanpouille-Box  19 , Erik Wennerberg  19 , Karsten A. Pilones  19   20 , Silvia C. Formenti  21 , Sandra Demaria  19   20 , Haidong Tang  22 , Yang Wang  22 , Yang-Xin Fu  22 , Reinhard Dummer  23   24   25   26 , Igor Puzanov  27   28 , Ahmad Tarhini  29 , Joe-Marc Chauvin  30   31 , Ornella Pagliano  30   31 , Julien Fourcade  30   31 , Zhaojun Sun  30   31 , Hong Wang  31   32 , Cindy Sanders  30   31 , John M. Kirkwood  30   31   33   34 , Tseng-hui Timothy Chen  31   35 , Mark Maurer  31   35 , Alan J. Korman  31   35 , Hassane M. Zarour  30   31   32   35 , David F. Stroncek  36 , Veronica Huber  37 , Licia Rivoltini  37 , Magdalena Thurin  38 , Tilman Rau  39 , Alessandro Lugli  39 , Franck Pagès  40   41 , Jorge Camarero  42 , Arantxa Sancho  43 , Claudio Jommi  44   45 , Yago Pico de Coaña  46 , Maria Wolodarski  46 , Yuya Yoshimoto  46 , Giusy Gentilcore  46   47 , Isabel Poschke  46   48 , Giuseppe V. Masucci  46 , Johan Hansson  46 , Rolf Kiessling  46 , Giosuè Scognamiglio  49   50   36   51 , Francesco Sabbatino  52   53 , Federica Zito Marino  49 , Anna Maria Anniciello  49   54 , Monica Cantile  49   54   51 , Margherita Cerrone  49   54 , Stefania Scala  55 , Crescenzo D’alterio  55 , Angela Ianaro  56 , Giuseppe Cirin  56 , Giuseppina Liguori  49 , Gerardo Bott  49 , Paul B. Chapman  57 , Caroline Robert  58   59   60   61   62   63 , James Larkin  64 , John B. Haanen  65 , Antoni Ribas  66   67 , David Hogg  68 , Omid Hamid  69   70   71 , Alessandro Testori  72 , Paul Lorigan  73 , Jeffrey A. Sosman  74 , Keith T. Flaherty  75 , Huibin Yue  76 , Shelley Coleman  77 , Ivor Caro  78 , Axel Hauschild  79 , Grant A. McArthur  80   81 , Mario Sznol  82 , Margaret K. Callahan  83 , Harriet Kluger  82 , Michael A. Postow  83   84 , RuthAnn Gordan  83 , Neil H. Segal  83 , Naiyer A. Rizvi  83 , Alexander Lesokhin  83 , Michael B. Atkins  85 , Matthew M. Burke  82 , Amanda Ralabate  82 , Angel Rivera  82 , Stephanie A. Kronenberg  83 , Blessing Agunwamba  83 , Mary Ruisi  86 , Christine Horak  87 , Joel Jiang  86 , Jedd Wolchok  83   88 , Paolo A. Ascierto  87   89   90 , Gabriella Liszkay  91   92 , Michele Maio  93   94   95 , Mario Mandalà  96 , Lev Demidov  97 , Daniil Stoyakovskiy  98 , Luc Thomas  99 , Luis de la Cruz-Merino  100 , Victoria Atkinson  101   102   103 , Caroline Dutriaux  104   105 , Claus Garbe  106 , Matthew Wongchenko  107 , Ilsung Chang  108 , Daniel O. Koralek  108 , Isabelle Rooney  108 , Yibing Yan  107 , Brigitte Dréno  109 , Ryan Sullivan  110 , Manish Patel  111 , Stephen Hodi  110 , Rodabe Amaria  2 , Peter Boasberg  70 , Jeffrey Wallin  112 , Xian He  112 , Edward Cha  112 , Nicole Richie  112 , Marcus Ballinger  112 , David C. Smith  113 , Todd M. Bauer  114 , Jeffrey S. Wasser  115 , Jason J. Luke  116 , Ani S. Balmanoukian  16 , David R. Kaufman  117   118 , Yufan Zhao  119 , Janet Maleski  119 , Lance Leopold  119 , Tara C. Gangadhar  120 , Georgina V. Long  121   89   122 , Olivier Michielin  123 , Ari VanderWalde  124 , Robert H. I. Andtbacka  125 , Jonathan Cebon  126 , Eugenio Fernandez  127 , Josep Malvehy  128 , Anthony J. Olszanski  129 , Christine Gause  118 , Lisa Chen  130 , Jeffrey Chou  130 , F. Stephen Hodi  110 , Benjamin Brady  131 , Laurent Mortier  132 , Jessica C. Hassel  133 , Piotr Rutkowski  134 , Catriona McNeil  135   136 , Ewa Kalinka-Warzocha  137 , Celeste Lebbé  138 , Lars Ny  139 , Matias Chacon  140 , Paola Queirolo  141 , Carmen Loquai  142 , Parneet Cheema  143 , Alfonso Berrocal  144 , Karmele Mujika Eizmendi  145 , Gil Bar-Sela  146 , Christine Horak  147 , Helene Hardy  147 , Jeffrey S. Weber  148 , Jean-Jacques Grob  149 , Ivan Marquez-Rodas  150 , Henrik Schmidt  151 , Karen Briscoe  152 , Jean-François Baurain  153 , Jedd D. Wolchok  154   155 , Rosamaria Pinto  156 , Simona De Summa  156 , Vito Michele Garrisi  156 , Sabino Strippoli  156   157 , Amalia Azzariti  156   157 , Gabriella Guida  158   159 , Michele Guida  156   157 , Stefania Tommasi  156   157 , Nicolas Jacquelot  160   161   162   160   163 , David Enot  162   164 , Caroline Flament  160   162   165 , Jonathan M. Pitt  160   162 , Nadège Vimond  162   165   166 , Carolin Blattner  167   168 , Takahiro Yamazaki  160   162 , Maria-Paula Roberti  160   162 , Marie Vetizou  160   162 , Romain Daillere  160   161   162 , Vichnou Poirier-Colame  160   162 , Michaë la Semeraro  160   169 , Anne Caignard  170 , Craig L Slingluff Jr  171 , Federica Sallusto  172 , Sylvie Rusakiewicz  160   161   162   165   160   61 , Benjamin Weide  173   174   175 , Aurélien Marabelle  160   162   160   61   161 , Holbrook Kohrt  176   176 , Stéphane Dalle  177   177 , Andréa Cavalcanti  162   61   62   178 , Guido Kroemer  162   164   179   180   181   182   183   61   164   184   179   181   182   183 , Anna Maria Di Giacomo  185 , Michaele Maio  186 , Phillip Wong  88 , Jianda Yuan  88 , Viktor Umansky  167   168 , Alexander Eggermont  162   61 , Laurence Zitvogel  160   161   162   165   160   163   61 , Passarelli Anna  187 , Tucci Marco  187 , Stucci Stefania  187 , Mannavola Francesco  187 , Capone Mariaelena  188 , Madonna Gabriele  188 , Ascierto Paolo Antonio  188 , Silvestris Franco  187 , María Paula Roberti  160   163   61 , David P. Enot  61   164 , Michaela Semeraro  160   61   169 , Sarah Jégou  189 , Camila Flores  61 , Tseng-hui Timothy Chen  184 , Byoung S. Kwon  190   191 , Ana Carrizossa Anderson  192 , Christophe Borg  193   194   195 , François Aubin  196 , Maha Ayyoub  160   163   61   161 , Anna Lisa De Presbiteris  197 , Fabiola Gilda Cordaro  197 , Rosa Camerlingo  90   9   198 , Federica Fratangelo  90   9   4 , Nicola Mozzillo  90 , Giuseppe Pirozzi  90   9   198 , Eduardo J. Patriarca  197 , Emilia Caputo  197   199 , Maria Letizia Motti  9   200   4   201 , Rosaria Falcon  9   10 , Roberta Miceli  9 , Mariaelena Capone  9 , Gabriele Madonna  9 , Domenico Mallardo  9 , Maria Vincenza Carrier  9   4 , Elisabetta Panza  56 , Paola De Cicco  56 , Chiara Armogida  56 , Giuseppe Ercolano  56 , Gerardo Botti  49   50   54   51 , Giuseppe Cirino  56 , Angela Sandru  202   203   204   205 , Miri Blank  206 , Timea Balatoni  92 , Judit Olasz  207 , Emil Farkas  208 , Andras Szollar  208 , Akos Savolt  208 , Maria Godeny  209 , Orsolya Csuka  207 , Szabolcs Horvath  203 , Klara Eles  203 , Yehuda Shoenfeld  206 , Miklos Kasler  210 , Susan Costantini  3 , Francesca Capone  3 , Farnaz Moradi  12 , Pontus Berglund  12 , Karin Leandersson  13 , Rickard Linnskog  12 , Tommy Andersson  12 , Chandra Prakash Prasad  12 , Cristiana Lo Nigro  211 , Laura Lattanzio  211 , Hexiao Wang  212 , Charlotte Proby  212 , Nelofer Syed  213 , Marcella Occelli  214 , Carolina Cauchi  214 , Marco Merlano  214 , Catherine Harwood  215 , Alastair Thompson  212 , Tim Crook  212 , Katia Bifulco  4 , Vincenzo Ingangi  4 , Michele Minopoli  4 , Concetta Ragone  4 , Antonello Pessi  216 , Francesco Mannavola  217 , Stella D’Oronzo  217 , Claudia Felici  217 , Marco Tucci  217 , Antonio Doronzo  217 , Franco Silvestris  217 , Anna Ferretta  157   159 , Stefania Guida  159 , Imma Maida  159 , Tiziana Cocco  159 , Anna Passarelli  217 , Davide Quaresmini  217 , Ornella Franzese  218 , Belinda Palermo  219 , Cosmo Di Donna  219 , Isabella Sperduti  220 , MariaLaura Foddai  219 , Helena Stabile  221 , Angela Gismondi  221 , Angela Santoni  221 , Paola Nisticò  219 , Andrea P. Sponghini  222 , Francesca Platini  222 , Elena Marra  223 , David Rondonotti  222 , Oscar Alabiso  222 , Maria T. Fierro  223 , Paola Savoia  223 , Florian Stratica  222 , Pietro Quaglino  223 , Gianluca Di Monta  224 , Caracò Corrado  224 , Massimiliano Di Marzo  224 , Marone Ugo  224 , Maria Luisa Di Cecilia  224 , Mozzillo Nicola  224 , Celeste Fusciello  53 , Antonio Marra  53 , Rosario Guarrasi  53 , Carlo Baldi  53 , Rosa Russo  53 , Giovanni Di Giulio  53 , Vincenzo Faiola  53 , Pio Zeppa  53 , Stefano Pepe  53 , Elisabetta Gambale  225 , Consiglia Carella  225 , Alessandra Di Paolo  225 , Michele De Tursi  225 , Laura Marra  54   51 , Fara De Murtas  54 , Valeria Sorrentino  54 , Silviu Voinea  204   205 , Eugenia Panaitescu  226 , Madalina Bolovan  227 , Adina Stanciu  227 , Sabin Cinca  227 , Chiara Botti  10 , Gabriella Aquino  51 , Annamaria Anniciello  51 , Cristina Fortes  228 , Simona Mastroeni  228 , Alessio Caggiati  229 , Francesca Passarelli  230 , Alba Zappalà  230 , Maria Capuano  231 , Riccardo Bono  232 , Maurizio Nudo  232 , Claudia Marino  232 , Paola Michelozzi  232 , Valeria De Biasio  233 , Vincenzo C. Battarra  234 , Silvia Formenti  21 , Maria Libera Ascierto  235 , Tracee L. McMiller  236 , Alan E. Berger  237 , Ludmila Danilova  235   238 , Robert A. Anders  239 , George J. Netto  239 , Haiying Xu  240 , Theresa S. Pritchard  236 , Jinshui Fan  237 , Chris Cheadle  237 , Leslie Cope  235   238 , Charles G. Drake  235   241 , Drew M. Pardoll  235 , Janis M. Taube  239   240 , Suzanne L. Topalian  236 , Sacha Gnjatic  242 , Sarah Nataraj  242 , Naoko Imai  242 , Adeeb Rahman  242 , Achim A. Jungbluth  88 , Linda Pan  243 , Ralph Venhaus  243 , Andrew Park  243 , Frédéric F. Lehmann  244 , Nikoletta Lendvai  88 , Adam D. Cohen  245 , Hearn J. Cho  242 , Speiser Daniel  246   247 , Vera Hirsh  248
Affiliations

Melanoma and immunotherapy bridge 2015 : Naples, Italy. 1-5 December 2015

Vashisht G. Y. Nanda et al. J Transl Med. .

Abstract

MELANOMA BRIDGE 2015

KEYNOTE SPEAKER PRESENTATIONS

Molecular and immuno-advances

K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanoma

Vashisht G. Y. Nanda, Weiyi Peng, Patrick Hwu, Michael A. Davies

K2 Non-mutational adaptive changes in melanoma cells exposed to BRAF and MEK inhibitors help the establishment of drug resistance

Gennaro Ciliberto, Luigi Fattore, Debora Malpicci, Luigi Aurisicchio, Paolo Antonio Ascierto, Carlo M. Croce, Rita Mancini

K3 Tumor-intrinsic beta-catenin signaling mediates tumor-immune avoidance

Stefani Spranger, Thomas F. Gajewski

K4 Intracellular tumor antigens as a source of targets of antibody-based immunotherapy of melanoma

Yangyang Wang, Soldano Ferrone

Combination therapies

K5 Harnessing radiotherapy to improve responses to immunotherapy in cancer

Claire Vanpouille-Box, Erik Wennerberg, Karsten A. Pilones, Silvia C. Formenti, Sandra Demaria

K6 Creating a T cell-inflamed tumor microenvironment overcomes resistance to checkpoint blockade

Haidong Tang, Yang Wang, Yang-Xin Fu

K7 Biomarkers for treatment decisions?

Reinhard Dummer

K8 Combining oncolytic therapies in the era of checkpoint inhibitors

Igor Puzanov

K9 Immune checkpoint blockade for melanoma: should we combine or sequence ipilimumab and PD-1 antibody therapy?

Michael A. Postow

News in immunotherapy

K10 An update on adjuvant and neoadjuvant therapy for melanom

Ahmad Tarhini

K11 Targeting multiple inhibitory receptors in melanoma

Joe-Marc Chauvin, Ornella Pagliano, Julien Fourcade, Zhaojun Sun, Hong Wang, Cindy Sanders, John M. Kirkwood, Tseng-hui Timothy Chen, Mark Maurer, Alan J. Korman, Hassane M. Zarour

K12 Improving adoptive immune therapy using genetically engineered T cells

David F. Stroncek

Tumor microenvironment and biomarkers

K13 Myeloid cells and tumor exosomes: a crosstalk for assessing immunosuppression?

Veronica Huber, Licia Rivoltini

K14 Update on the SITC biomarker taskforce: progress and challenges

Magdalena Thurin

World-wide immunoscore task force: an update

K15 The immunoscore in colorectal cancer highlights the importance of digital scoring systems in surgical pathology

Tilman Rau, Alessandro Lugli

K16 The immunoscore: toward an integrated immunomonitoring from the diagnosis to the follow up of cancer’s patients

Franck Pagès

Economic sustainability of melanoma treatments: regulatory, health technology assessment and market access issues

K17 Nivolumab, the regulatory experience in immunotherapy

Jorge Camarero, Arantxa Sancho

K18 Evidence to optimize access for immunotherapies

Claudio Jommi

ORAL PRESENTATIONS

Molecular and immuno-advances

O1 Ipilimumab treatment results in CD4 T cell activation that is concomitant with a reduction in Tregs and MDSCs

Yago Pico de Coaña, Maria Wolodarski, Yuya Yoshimoto, Giusy Gentilcore, Isabel Poschke, Giuseppe V. Masucci, Johan Hansson, Rolf Kiessling

O2 Evaluation of prognostic and therapeutic potential of COX-2 and PD-L1 in primary and metastatic melanoma

Giosuè Scognamiglio, Francesco Sabbatino, Federica Zito Marino, Anna Maria Anniciello, Monica Cantile, Margherita Cerrone, Stefania Scala, Crescenzo D’alterio, Angela Ianaro, Giuseppe Cirino, Paolo Antonio Ascierto, Giuseppina Liguori, Gerardo Botti

O3 Vemurafenib in patients with BRAFV600 mutation–positive metastatic melanoma: final overall survival results of the BRIM-3 study

Paul B. Chapman, Caroline Robert, James Larkin, John B. Haanen, Antoni Ribas, David Hogg, Omid Hamid, Paolo Antonio Ascierto, Alessandro Testori, Paul Lorigan, Reinhard Dummer, Jeffrey A. Sosman, Keith T. Flaherty, Huibin Yue, Shelley Coleman, Ivor Caro, Axel Hauschild, Grant A. McArthur

O4 Updated survival, response and safety data in a phase 1 dose-finding study (CA209-004) of concurrent nivolumab (NIVO) and ipilimumab (IPI) in advanced melanoma

Mario Sznol, Margaret K. Callahan, Harriet Kluger, Michael A. Postow, RuthAnn Gordan, Neil H. Segal, Naiyer A. Rizvi, Alexander Lesokhin, Michael B. Atkins, John M. Kirkwood, Matthew M. Burke, Amanda Ralabate, Angel Rivera, Stephanie A. Kronenberg, Blessing Agunwamba, Mary Ruisi, Christine Horak, Joel Jiang, Jedd Wolchok

Combination therapies

O5 Efficacy and correlative biomarker analysis of the coBRIM study comparing cobimetinib (COBI) + vemurafenib (VEM) vs placebo (PBO) + VEM in advanced BRAF-mutated melanoma patients (pts)

Paolo A. Ascierto, Grant A. McArthur, James Larkin, Gabriella Liszkay, Michele Maio, Mario Mandalà, Lev Demidov, Daniil Stoyakovskiy, Luc Thomas, Luis de la Cruz-Merino, Victoria Atkinson, Caroline Dutriaux, Claus Garbe, Matthew Wongchenko, Ilsung Chang, Daniel O. Koralek, Isabelle Rooney, Yibing Yan, Antoni Ribas, Brigitte Dréno

O6 Preliminary clinical safety, tolerability and activity results from a Phase Ib study of atezolizumab (anti-PDL1) combined with vemurafenib in BRAFV600-mutant metastatic melanoma

Ryan Sullivan, Omid Hamid, Manish Patel, Stephen Hodi, Rodabe Amaria, Peter Boasberg, Jeffrey Wallin, Xian He, Edward Cha, Nicole Richie, Marcus Ballinger, Patrick Hwu

O7 Preliminary safety and efficacy data from a phase 1/2 study of epacadostat (INCB024360) in combination with pembrolizumab in patients with advanced/metastatic melanoma

Thomas F. Gajewski, Omid Hamid, David C. Smith, Todd M. Bauer, Jeffrey S. Wasser, Jason J. Luke, Ani S. Balmanoukian, David R. Kaufman, Yufan Zhao, Janet Maleski, Lance Leopold, Tara C. Gangadhar

O8 Primary analysis of MASTERKEY-265 phase 1b study of talimogene laherparepvec (T-VEC) and pembrolizumab (pembro) for unresectable stage IIIB-IV melanoma

Reinhard Dummer, Georgina V. Long, Antoni Ribas, Igor Puzanov, Olivier Michielin, Ari VanderWalde, Robert H.I. Andtbacka, Jonathan Cebon, Eugenio Fernandez, Josep Malvehy, Anthony J. Olszanski, Thomas F. Gajewski, John M. Kirkwood, Christine Gause, Lisa Chen, David R. Kaufman, Jeffrey Chou, F. Stephen Hodi

News in immunotherapy

O9 Two-year survival and safety update in patients (pts) with treatment-naïve advanced melanoma (MEL) receiving nivolumab (NIVO) or dacarbazine (DTIC) in CheckMate 066

Victoria Atkinson, Paolo A. Ascierto, Georgina V. Long, Benjamin Brady, Caroline Dutriaux, Michele Maio, Laurent Mortier, Jessica C. Hassel, Piotr Rutkowski, Catriona McNeil, Ewa Kalinka-Warzocha, Celeste Lebbé, Lars Ny, Matias Chacon, Paola Queirolo, Carmen Loquai, Parneet Cheema, Alfonso Berrocal, Karmele Mujika Eizmendi, Luis De La Cruz-Merino, Gil Bar-Sela, Christine Horak, Joel Jiang, Helene Hardy, Caroline Robert

O10 Efficacy and safety of nivolumab (NIVO) in patients (pts) with advanced melanoma (MEL) who were treated beyond progression in CheckMate 066/067

Georgina V. Long, Jeffrey S. Weber, James Larkin, Victoria Atkinson, Jean-Jacques Grob, Reinhard Dummer, Caroline Robert, Ivan Marquez-Rodas, Catriona McNeil, Henrik Schmidt, Karen Briscoe, Jean-François Baurain, F. Stephen Hodi, Jedd D. Wolchok

Tumor microenvironment and biomarkers

O11 New biomarkers for response/resistance to BRAF inhibitor therapy in metastatic melanoma

Rosamaria Pinto, Simona De Summa, Vito Michele Garrisi, Sabino Strippoli, Amalia Azzariti, Gabriella Guida, Michele Guida, Stefania Tommasi

O12 Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma and response to ipilimumab

Nicolas Jacquelot, David Enot, Caroline Flament, Jonathan M. Pitt, Nadège Vimond, Carolin Blattner, Takahiro Yamazaki, Maria-Paula Roberti, Marie Vetizou, Romain Daillere, Vichnou Poirier-Colame, Michaëla Semeraro, Anne Caignard, Craig L Slingluff Jr, Federica Sallusto, Sylvie Rusakiewicz, Benjamin Weide, Aurélien Marabelle, Holbrook Kohrt, Stéphane Dalle, Andréa Cavalcanti, Guido Kroemer, Anna Maria Di Giacomo, Michaele Maio, Phillip Wong, Jianda Yuan, Jedd Wolchok, Viktor Umansky, Alexander Eggermont, Laurence Zitvogel

O13 Serum levels of PD1- and CD28-positive exosomes before Ipilimumab correlate with therapeutic response in metastatic melanoma patients

Passarelli Anna, Tucci Marco, Stucci Stefania, Mannavola Francesco, Capone Mariaelena, Madonna Gabriele, Ascierto Paolo Antonio, Silvestris Franco

O14 Immunological prognostic factors in stage III melanomas

María Paula Roberti, Nicolas Jacquelot, David P Enot, Sylvie Rusakiewicz, Michaela Semeraro, Sarah Jégou, Camila Flores, Lieping Chen, Byoung S. Kwon, Ana Carrizossa Anderson, Caroline Robert, Christophe Borg, Benjamin Weide, François Aubin, Stéphane Dalle, Michele Maio, Jedd D. Wolchok, Holbrook Kohrt, Maha Ayyoub, Guido Kroemer, Aurélien Marabelle, Andréa Cavalcanti, Alexander Eggermont, Laurence Zitvogel

POSTER PRESENTATIONS

Molecular and immuno-advances

P1 Human melanoma cells resistant to B-RAF and MEK inhibition exhibit mesenchymal-like features

Anna Lisa De Presbiteris, Fabiola Gilda Cordaro, Rosa Camerlingo, Federica Fratangelo, Nicola Mozzillo, Giuseppe Pirozzi, Eduardo J. Patriarca, Paolo A. Ascierto, Emilia Caputo

P2 Anti-proliferative and pro-apoptotic effect of ABT888 on melanoma cell lines and its potential role in the treatment of melanoma resistant to B-RAF inhibitors

Federica Fratangelo, Rosa Camerlingo, Emilia Caputo, Maria Letizia Motti, Rosaria Falcone, Roberta Miceli, Mariaelena Capone, Gabriele Madonna, Domenico Mallardo, Maria Vincenza Carriero, Giuseppe Pirozzi and Paolo Antonio Ascierto

P3 Involvement of the L-cysteine/CSE/H2S pathway in human melanoma progression

Elisabetta Panza, Paola De Cicco, Chiara Armogida, Giuseppe Ercolano, Rosa Camerlingo, Giuseppe Pirozzi, Giosuè Scognamiglio, Gerardo Botti, Giuseppe Cirino, Angela Ianaro

P4 Cancer stem cell antigen revealing pattern of antibody variable region genes were defined by immunoglobulin repertoire analysis in patients with malignant melanoma

Beatrix Kotlan, Gabriella Liszkay, Miri Blank, Timea Balatoni, Judit Olasz, Emil Farkas, Andras Szollar, Akos Savolt, Maria Godeny, Orsolya Csuka, Szabolcs Horvath, Klara Eles, Yehuda Shoenfeld and Miklos Kasler

P5 Upregulation of Neuregulin-1 expression is a hallmark of adaptive response to BRAF/MEK inhibitors in melanoma

Debora Malpicci, Luigi Fattore, Susan Costantini, Francesca Capone, Paolo Antonio Ascierto, Rita Mancini, Gennaro Ciliberto

P6 HuR positively regulates migration of HTB63 melanoma cells

Farnaz Moradi, Pontus Berglund, Karin Leandersson, Rickard Linnskog, Tommy Andersson, Chandra Prakash Prasad

P7 Prolyl 4- (C-P4H) hydroxylases have opposing effects in malignant melanoma: implication in prognosis and therapy

Cristiana Lo Nigro, Laura Lattanzio, Hexiao Wang, Charlotte Proby, Nelofer Syed, Marcella Occelli, Carolina Cauchi, Marco Merlano, Catherine Harwood, Alastair Thompson, Tim Crook

P8 Urokinase receptor antagonists: novel agents for the treatment of melanoma

Maria Letizia Motti, Katia Bifulco, Vincenzo Ingangi, Michele Minopoli, Concetta Ragone, Federica Fratangelo, Antonello Pessi, Gennaro Ciliberto, Paolo Antonio Ascierto, Maria Vincenza Carriero

P9 Exosomes released by melanoma cell lines enhance chemotaxis of primary tumor cells

Francesco Mannavola, Stella D’Oronzo, Claudia Felici, Marco Tucci, Antonio Doronzo, Franco Silvestris

P10 New insights in mitochondrial metabolic reprogramming in melanoma

Anna Ferretta, Gabriella Guida, Stefania Guida, Imma Maida, Tiziana Cocco, Sabino Strippoli, Stefania Tommasi, Amalia Azzariti, Michele Guida

P11 Lenalidomide restrains the proliferation in melanoma cells through a negative regulation of their cell cycle

Stella D’Oronzo, Anna Passarelli, Claudia Felici, Marco Tucci, Davide Quaresmini, Franco Silvestris

Combination therapies

P12 Chemoimmunotherapy elicits polyfunctional anti-tumor CD8 + T cells depending on the activation of an AKT pathway sustained by ICOS

Ornella Franzese, Belinda Palermo, Cosmo Di Donna, Isabella Sperduti, MariaLaura Foddai, Helena Stabile, Angela Gismondi, Angela Santoni, Paola Nisticò

P13 Favourable toxicity profile of combined BRAF and MEK inhibitors in metastatic melanoma patients

Andrea P. Sponghini, Francesca Platini, Elena Marra, David Rondonotti, Oscar Alabiso, Maria T. Fierro, Paola Savoia, Florian Stratica, Pietro Quaglino

P14 Electrothermal bipolar vessel sealing system dissection reduces seroma output or time to drain removal following axillary and ilio-inguinal node dissection in melanoma patients: a pilot study

Di Monta Gianluca, Caracò Corrado, Di Marzo Massimiliano, Marone Ugo, Di Cecilia Maria Luisa, Mozzillo Nicola

News in immunotherapy

P15 Clinical and immunological response to ipilimumab in a metastatic melanoma patient with HIV infection

Francesco Sabbatino, Celeste Fusciello1, Antonio Marra, Rosario Guarrasi, Carlo Baldi, Rosa Russo, Di Giulio Giovanni, Vincenzo Faiola, Pio Zeppa, Stefano Pepe

P16 Immunotherapy and hypophysitis: a case report

Elisabetta Gambale, Consiglia Carella, Alessandra Di Paolo, Michele De Tursi

Tumor microenvironment and biomarkers

P17 New immuno- histochemical markers for the differential diagnosis of atypical melanocytic lesions with uncertain malignant potential

Laura Marra, Giosuè Scognamiglio, Monica Cantile, Margherita Cerrone, Fara De Murtas, Valeria Sorrentino, Anna Maria Anniciello, Gerardo Botti

P18 Utility of simultaneous measurement of three serum tumor markers in melanoma patients

Angela Sandru, Silviu Voinea, Eugenia Panaitescu, Madalina Bolovan, Adina Stanciu, Sabin Cinca

P19 The significance of various cut-off levels of melanoma inhibitory activity in evaluation of cutaneous melanoma patients

Angela Sandru, Silviu Voinea, Eugenia Panaitescu, Madalina Bolovan, Adina Stanciu, Sabin Cinca

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