Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Aug 16;55(34):9984-7.
doi: 10.1002/anie.201604827. Epub 2016 Jul 13.

On-Demand Dissolution of a Dendritic Hydrogel-based Dressing for Second-Degree Burn Wounds through Thiol-Thioester Exchange Reaction

Marlena D Konieczynska  1 , Juan C Villa-Camacho  2 , Cynthia Ghobril  1 , Miguel Perez-Viloria  2 , Kristie M Tevis  1 , William A Blessing  1 , Ara Nazarian  2 , Edward K Rodriguez  2 , Mark W Grinstaff  3
Affiliations

On-Demand Dissolution of a Dendritic Hydrogel-based Dressing for Second-Degree Burn Wounds through Thiol-Thioester Exchange Reaction

Marlena D Konieczynska et al. Angew Chem Int Ed Engl. .

Abstract

An adhesive yet easily removable burn wound dressing represents a breakthrough in second-degree burn wound care. Current second-degree burn wound dressings absorb wound exudate, reduce bacterial infections, and maintain a moist environment for healing, but are surgically or mechanically debrided from the wound, causing additional trauma to the newly formed tissues. We have developed an on-demand dissolvable dendritic thioester hydrogel burn dressing for second-degree burn care. The hydrogel is composed of a lysine-based dendron and a PEG-based crosslinker, which are synthesized in high yields. The hydrogel burn dressing covers the wound and acts as a barrier to bacterial infection in an in vivo second-degree burn wound model. A unique feature of the hydrogel is its capability to be dissolved on-demand, via a thiol-thioester exchange reaction, allowing for a facile burn dressing removal.

Keywords: dendrimers; dissolution; hydrogel; thiol-thioester exchange; wound dressing.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A. An idealized crosslinked hydrogel formed by the reaction between the dendron and crosslinker. B. On-demand dissolution of the hydrogel relies on a thiol-thioester exchange reaction upon exposure to a CME solution.
Figure 2
Figure 2
Time sweep of hydrogel dissolution after exposure of the hydrogel to CME, LME, or air.
Figure 3
Figure 3
Photographs of the dissolution of the hydrogel as a function of time after treatment with an aqueous CME solution (0.3 M, pH 8.6). Fast Green FCF was added to the hydrogel for visualization.
Figure 4
Figure 4
Local and systemic Pseudomonal burden by group. * P < 0.001; ** P = 0.013.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Wasiak J, Cleland H, Campbell F, Spinks A. Cochrane Database Syst Rev. 2013;3:CD002106. - PMC - PubMed
    1. Queen D, Evans JH, Gaylor JDS, Courtney JM, Reid WH. Burns. 1987;13:218–228. - PubMed
    2. Madaghiele M, Demitri C, Sannino A, Ambrosio L. Burns Trauma. 2015;2:153–161. - PMC - PubMed
    1. Atchison NE, Osgood PF, Carr DB, Szyfelbein SK. Pain. 1991;47:41–45. - PubMed
    1. Latarjet J, Choinere M. Burns. 1995;21:344–348. - PubMed
    1. Beushausen T, Mucke K. Pediatr Surg Int. 1997;12:327–333. - PubMed

Publication types