Shape Transitions and Chiral Symmetry Breaking in the Energy Landscape of the Mitotic Chromosome
- PMID: 27367409
- DOI: 10.1103/PhysRevLett.116.248101
Shape Transitions and Chiral Symmetry Breaking in the Energy Landscape of the Mitotic Chromosome
Abstract
We derive an unbiased information theoretic energy landscape for chromosomes at metaphase using a maximum entropy approach that accurately reproduces the details of the experimentally measured pairwise contact probabilities between genomic loci. Dynamical simulations using this landscape lead to cylindrical, helically twisted structures reflecting liquid crystalline order. These structures are similar to those arising from a generic ideal homogenized chromosome energy landscape. The helical twist can be either right or left handed so chiral symmetry is broken spontaneously. The ideal chromosome landscape when augmented by interactions like those leading to topologically associating domain formation in the interphase chromosome reproduces these behaviors. The phase diagram of this landscape shows that the helical fiber order and the cylindrical shape persist at temperatures above the onset of chiral symmetry breaking, which is limited by the topologically associating domain interaction strength.
Similar articles
-
Topology, structures, and energy landscapes of human chromosomes.Proc Natl Acad Sci U S A. 2015 May 12;112(19):6062-7. doi: 10.1073/pnas.1506257112. Epub 2015 Apr 27. Proc Natl Acad Sci U S A. 2015. PMID: 25918364 Free PMC article.
-
Density functional theory for chiral nematic liquid crystals.Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Aug;90(2):020503. doi: 10.1103/PhysRevE.90.020503. Epub 2014 Aug 27. Phys Rev E Stat Nonlin Soft Matter Phys. 2014. PMID: 25215676
-
Entropy-driven formation of chiral nematic phases by computer simulations.Nat Commun. 2016 Apr 12;7:11175. doi: 10.1038/ncomms11175. Nat Commun. 2016. PMID: 27067806 Free PMC article.
-
Spontaneous achiral symmetry breaking in liquid crystalline phases.Top Curr Chem. 2012;318:303-30. doi: 10.1007/128_2011_242. Top Curr Chem. 2012. PMID: 21915774 Review.
-
Mirror Symmetry Breaking by Chirality Synchronisation in Liquids and Liquid Crystals of Achiral Molecules.Chemphyschem. 2016 Jan 4;17(1):9-26. doi: 10.1002/cphc.201500601. Epub 2015 Oct 13. Chemphyschem. 2016. PMID: 26416335 Review.
Cited by
-
Chromosome disentanglement driven via optimal compaction of loop-extruded brush structures.Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):24956-24965. doi: 10.1073/pnas.1906355116. Epub 2019 Nov 22. Proc Natl Acad Sci U S A. 2019. PMID: 31757850 Free PMC article.
-
Anomalous diffusion, spatial coherence, and viscoelasticity from the energy landscape of human chromosomes.Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7753-7758. doi: 10.1073/pnas.1806297115. Epub 2018 Jul 9. Proc Natl Acad Sci U S A. 2018. PMID: 29987017 Free PMC article.
-
Large-scale data-driven and physics-based models offer insights into the relationships among the structures, dynamics, and functions of chromosomes.J Mol Cell Biol. 2023 Nov 27;15(6):mjad042. doi: 10.1093/jmcb/mjad042. J Mol Cell Biol. 2023. PMID: 37365687 Free PMC article. Review.
-
Interphase human chromosome exhibits out of equilibrium glassy dynamics.Nat Commun. 2018 Aug 8;9(1):3161. doi: 10.1038/s41467-018-05606-6. Nat Commun. 2018. PMID: 30089831 Free PMC article.
-
From 1D sequence to 3D chromatin dynamics and cellular functions: a phase separation perspective.Nucleic Acids Res. 2018 Oct 12;46(18):9367-9383. doi: 10.1093/nar/gky633. Nucleic Acids Res. 2018. PMID: 30053116 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
