Comparative analysis of the expression patterns of eight suppressors of cytokine signaling in tongue sole, Cynoglossus semilaevis
- PMID: 27346156
- DOI: 10.1016/j.fsi.2016.06.034
Comparative analysis of the expression patterns of eight suppressors of cytokine signaling in tongue sole, Cynoglossus semilaevis
Abstract
Suppressor of cytokine signaling (SOCS) family members are inhibitors of cytokine signaling pathways and key regulators of immunological homeostasis. They have been extensively studied in mammalian models, but systematic analyses of SOCS in fish are limited. In the current study, a total of eight SOCS genes from tongue sole (Cynoglossus semilaevis) were characterized. All eight CsSOCS exhibit conserved structures of SOCS and were phylogenetically grouped together with the respective SCOS members known in mammalian and teleost species. Under normal physiological conditions, the expressions of the eight CsSOCS genes were detected at varied levels in nine major tissues, with most CsSOCS highly expressed in kidney. Following challenge with intracellular and extracellular bacterial pathogens, the majority of CsSOCS genes exhibited distinctly different expression profiles in a time-, tissue-, and pathogen-dependent manner. In general, intracellular pathogen caused wider and higher levels of CsSOCS expressions than extracellular pathogen. These results suggest that different members of SOCSs in teleost may play different roles in the infection processes of different bacterial pathogens.
Keywords: Bacterial infection; Cynoglossus semilaevis; Expression; Immune defense; Suppressor of cytokine signaling.
Copyright © 2016 Elsevier Ltd. All rights reserved.
Similar articles
-
Molecular characterization and expression analysis of nine CC chemokines in half-smooth tongue sole, Cynoglossus semilaevis.Fish Shellfish Immunol. 2015 Dec;47(2):717-24. doi: 10.1016/j.fsi.2015.10.003. Epub 2015 Oct 22. Fish Shellfish Immunol. 2015. PMID: 26470888
-
Molecular characterization and expression analysis of eleven interferon regulatory factors in half-smooth tongue sole, Cynoglossus semilaevis.Fish Shellfish Immunol. 2015 May;44(1):272-82. doi: 10.1016/j.fsi.2015.02.033. Epub 2015 Feb 28. Fish Shellfish Immunol. 2015. PMID: 25731919
-
A CCL21 chemokine of tongue sole (Cynoglossus semilaevis) promotes host resistance against bacterial infection.Fish Shellfish Immunol. 2015 Nov;47(1):461-9. doi: 10.1016/j.fsi.2015.09.036. Epub 2015 Sep 28. Fish Shellfish Immunol. 2015. PMID: 26416599
-
Molecular characterization reveals involvement of four caspases in the antibacterial immunity of tongue sole (Cynoglossus semilaevis).Fish Shellfish Immunol. 2016 Oct;57:340-349. doi: 10.1016/j.fsi.2016.08.047. Epub 2016 Aug 24. Fish Shellfish Immunol. 2016. PMID: 27566101
-
SOCS proteins in infectious diseases of mammals.Vet Immunol Immunopathol. 2013 Jan 15;151(1-2):1-19. doi: 10.1016/j.vetimm.2012.11.008. Epub 2012 Nov 20. Vet Immunol Immunopathol. 2013. PMID: 23219158 Free PMC article. Review.
Cited by
-
Molecular Cloning and Expression Analysis of Three Suppressors of Cytokine Signaling Genes (SOCS5, SOCS6, SOCS7) in the Mealworm Beetle Tenebrio molitor.Insects. 2019 Mar 16;10(3):76. doi: 10.3390/insects10030076. Insects. 2019. PMID: 30884777 Free PMC article.
-
Genomic evidence of adaptive evolution in the reptilian SOCS gene family.PeerJ. 2021 Jun 24;9:e11677. doi: 10.7717/peerj.11677. eCollection 2021. PeerJ. 2021. PMID: 34221740 Free PMC article.
-
SOCS Proteins as Regulators of Inflammatory Responses Induced by Bacterial Infections: A Review.Front Microbiol. 2017 Dec 12;8:2431. doi: 10.3389/fmicb.2017.02431. eCollection 2017. Front Microbiol. 2017. PMID: 29312162 Free PMC article. Review.
-
Morphologic, cytometric, quantitative transcriptomic and functional characterisation provide insights into the haemocyte immune responses of Pacific abalone (Haliotis discus hannai).Front Immunol. 2024 Jul 2;15:1376911. doi: 10.3389/fimmu.2024.1376911. eCollection 2024. Front Immunol. 2024. PMID: 39015569 Free PMC article.
-
Transcriptome Analysis Reveals Effect of Dietary Probiotics on Immune Response Mechanism in Southern Catfish (Silurus meridionalis) in Response to Plesiomonas shigelloides.Animals (Basel). 2023 Jan 28;13(3):449. doi: 10.3390/ani13030449. Animals (Basel). 2023. PMID: 36766339 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
