Polypeptides of pneumonia virus of mice. I. Immunological cross-reactions and post-translational modifications
- PMID: 2732719
- DOI: 10.1099/0022-1317-70-6-1427
Polypeptides of pneumonia virus of mice. I. Immunological cross-reactions and post-translational modifications
Abstract
A murine polyclonal antiserum and monoclonal antibodies have been employed to identify pneumonia virus of mice (PVM) polypeptides in infected cells and to study post-translational modifications. Immunoprecipitation experiments using a murine polyclonal antiserum and a monoclonal antibody directed against a 39K protein have established an antigenic relationship between two PVM proteins and the N and P proteins of human respiratory syncytial virus. Although 20 virus-specific polypeptides have been identified in lysates of infected cells, evidence is presented that some of these are related and that the number of unique polypeptides probably does not exceed 11 or 12. The phosphoproteins of PVM have a pattern of mobilities more like that of the recently described pneumovirus causing rhinotracheitis in turkeys than that of human or bovine respiratory syncytial virus.
Similar articles
-
Polypeptides of pneumonia virus of mice. II. Characterization of the glycoproteins.J Gen Virol. 1989 Jun;70 ( Pt 6):1441-52. doi: 10.1099/0022-1317-70-6-1441. J Gen Virol. 1989. PMID: 2732720
-
Antigenic and polypeptide structure of turkey enteric coronaviruses as defined by monoclonal antibodies.J Gen Virol. 1989 Jul;70 ( Pt 7):1725-41. doi: 10.1099/0022-1317-70-7-1725. J Gen Virol. 1989. PMID: 2472464
-
Structural polypeptides of type II avian adenoviruses analyzed by monoclonal and polyclonal antibodies.Avian Dis. 1991 Jul-Sep;35(3):572-8. Avian Dis. 1991. PMID: 1719952
-
Monoclonal antibodies against avian reticuloendotheliosis virus: identification of strain-specific and strain-common epitopes.J Immunol. 1986 Jun 1;136(11):4237-42. J Immunol. 1986. PMID: 2422277
-
Production and characterization of murine monoclonal antibody against synthetic peptide of CD34.Hum Antibodies. 2013;22(1-2):1-8. doi: 10.3233/HAB-130265. Hum Antibodies. 2013. PMID: 24284303 Review.
Cited by
-
Pneumovirus in dogs with acute respiratory disease.Emerg Infect Dis. 2010 Jun;16(6):993-5. doi: 10.3201/eid1606.091778. Emerg Infect Dis. 2010. PMID: 20507755 Free PMC article.
-
Evaluation of pneumonia virus of mice as a possible human pathogen.J Virol. 2012 May;86(10):5829-43. doi: 10.1128/JVI.00163-12. Epub 2012 Mar 21. J Virol. 2012. PMID: 22438539 Free PMC article.
-
Sequence of the phosphoprotein gene of pneumonia virus of mice: expression of multiple proteins from two overlapping reading frames.J Virol. 1994 Aug;68(8):5330-4. doi: 10.1128/JVI.68.8.5330-5334.1994. J Virol. 1994. PMID: 8035533 Free PMC article.
-
Identification of a novel virulence factor in recombinant pneumonia virus of mice.J Virol. 2007 Sep;81(17):9490-501. doi: 10.1128/JVI.00364-07. Epub 2007 Jun 13. J Virol. 2007. PMID: 17567693 Free PMC article.
-
Molecular cloning of pneumonia virus of mice.J Virol. 1990 Apr;64(4):1869-72. doi: 10.1128/JVI.64.4.1869-1872.1990. J Virol. 1990. PMID: 2319655 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources