Therapeutic targeting of autophagy in myocardial infarction and heart failure
- PMID: 27308848
- DOI: 10.1080/14779072.2016.1202760
Therapeutic targeting of autophagy in myocardial infarction and heart failure
Abstract
Introduction: Myocardial infarction (MI) is the leading cause of death. When MI is not lethal, heart failure (HF) is a major consequence with high prevalence and poor prognosis. The targeting of autophagy represents a potentially therapeutic approach for the treatment of both pathologies.
Areas covered: PubMed searches were performed to discuss the current state of the art regarding the role of autophagy in MI and HF. We review available and potential approaches to modulate autophagy from a pharmacological and genetic perspective. We also discuss the targeting of autophagy in myocardial regeneration. Expert commentary: The targeting of autophagy has potential for the treatment of MI and HF. Autophagy is a process that takes place in virtually all cells of the body and thus, in order to evaluate this therapeutic approach in clinical trials, strategies that specifically target this process in the myocardium is required to avoid unwanted effects in other organs.
Keywords: Autophagy; cell death; heart failure; ischemia reperfusion; myocardial infarction; pharmacological target.
Similar articles
-
Cellular Therapy for Ischemic Heart Disease: An Update.Adv Exp Med Biol. 2019;1201:195-213. doi: 10.1007/978-3-030-31206-0_10. Adv Exp Med Biol. 2019. PMID: 31898788 Review.
-
[Stem cell therapy for myocardial regeneration: mechanisms and current clinical applications].G Ital Cardiol (Rome). 2008 Apr;9(4):234-50. G Ital Cardiol (Rome). 2008. PMID: 18543793 Review. Italian.
-
Targeting necroptosis as therapeutic potential in chronic myocardial infarction.J Biomed Sci. 2021 Apr 9;28(1):25. doi: 10.1186/s12929-021-00722-w. J Biomed Sci. 2021. PMID: 33836761 Free PMC article. Review.
-
Myocardial infarction and heart failure hospitalization rates in Maine, USA - variability along the urban-rural continuum.Rural Remote Health. 2008 Apr-Jun;8(2):980. Epub 2008 Jun 26. Rural Remote Health. 2008. PMID: 18627216
-
Adult Stem Cell Therapy for Cardiac Repair in Patients After Acute Myocardial Infarction Leading to Ischemic Heart Failure: An Overview of Evidence from the Recent Clinical Trials.Curr Cardiol Rev. 2017;13(3):223-231. doi: 10.2174/1573403X13666170502103833. Curr Cardiol Rev. 2017. PMID: 28464769 Free PMC article. Review.
Cited by
-
Alpha7 Nicotinic Acetylcholine Receptor Alleviates Inflammatory Bowel Disease Through Induction of AMPK-mTOR-p70S6K-Mediated Autophagy.Inflammation. 2019 Oct;42(5):1666-1679. doi: 10.1007/s10753-019-01027-9. Inflammation. 2019. PMID: 31236857
-
Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases.Cells. 2018 Dec 19;7(12):279. doi: 10.3390/cells7120279. Cells. 2018. PMID: 30572675 Free PMC article. Review.
-
TBC1D15/RAB7-regulated mitochondria-lysosome interaction confers cardioprotection against acute myocardial infarction-induced cardiac injury.Theranostics. 2020 Sep 14;10(24):11244-11263. doi: 10.7150/thno.46883. eCollection 2020. Theranostics. 2020. PMID: 33042281 Free PMC article.
-
Ribosome biogenesis in disease: new players and therapeutic targets.Signal Transduct Target Ther. 2023 Jan 9;8(1):15. doi: 10.1038/s41392-022-01285-4. Signal Transduct Target Ther. 2023. PMID: 36617563 Free PMC article. Review.
-
Procyanidin A1 alleviates DSS-induced ulcerative colitis via regulating AMPK/mTOR/p70S6K-mediated autophagy.J Physiol Biochem. 2022 Feb;78(1):213-227. doi: 10.1007/s13105-021-00854-5. Epub 2022 Jan 10. J Physiol Biochem. 2022. PMID: 35001346
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous
