Lack of transmission among healthcare workers in contact with a case of Middle East respiratory syndrome coronavirus infection in Thailand

doi:10.1186/s13756-016-0120-9

. 2016 May 23:5:21.

doi: 10.1186/s13756-016-0120-9. eCollection 2016.

Lack of transmission among healthcare workers in contact with a case of Middle East respiratory syndrome coronavirus infection in Thailand

Surasak Wiboonchutikul¹, Weerawat Manosuthi¹, Sirirat Likanonsakul¹, Chariya Sangsajja¹, Paweena Kongsanan¹, Ravee Nitiyanontakij¹, Varaporn Thientong¹, Hatairat Lerdsamran², Pilaipan Puthavathana³

Affiliations

¹ Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Nonthaburi, 11000 Thailand.
² Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
³ Faculty of Medical Technology, Mahidol University, Bangkok, Thailand ; Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

PMID: 27222710
PMCID: PMC4877934
DOI: 10.1186/s13756-016-0120-9

Lack of transmission among healthcare workers in contact with a case of Middle East respiratory syndrome coronavirus infection in Thailand

Surasak Wiboonchutikul et al. Antimicrob Resist Infect Control. 2016.

. 2016 May 23:5:21.

doi: 10.1186/s13756-016-0120-9. eCollection 2016.

Authors

Affiliations

¹ Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Nonthaburi, 11000 Thailand.
² Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.
³ Faculty of Medical Technology, Mahidol University, Bangkok, Thailand ; Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

PMID: 27222710
PMCID: PMC4877934
DOI: 10.1186/s13756-016-0120-9

Abstract

Introduction: A hospital-associated outbreak of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was reported. We aimed to assess the effectiveness of infection control measures among healthcare workers (HCWs) who were exposed to a MERS patient and/or his body fluids in our institute.

Methods: A descriptive study was conducted among HCWs who worked with a MERS patient in Bamrasnaradura Infectious Diseases Institute, Thailand, between 18 June and 3 July 2015. Contacts were defined as HCWs who worked in the patient's room or with the patient's body fluids. Serum samples from all contacts were collected within 14 days of last contact and one month later. Paired sera were tested for detection of MERS-CoV antibodies by using an indirect ELISA.

Results: Thirty-eight (88.4 %) of 43 identified contacts consented to enroll. The mean (SD) age was 38.1 (11.1) years, and 79 % were females. The median (IQR) cumulative duration of work of HCWs in the patient's room was 35 (20-165) minutes. The median (IQR) cumulative duration of work of HCWs with the patient's blood or body fluids in laboratory was 67.5 (43.7-117.5) minutes. All contacts reported 100 % compliance with hand hygiene, using N95 respirator, performing respirator fit test, wearing gown, gloves, eye protection, and cap during their entire working period. All serum specimens of contacts tested for MERS-CoV antibodies were negative.

Conclusions: We provide evidence of effective infection control practices against MERS-CoV transmission in a healthcare facility. Strict infection control precautions can protect HCWs. The optimal infection control measures for MERS-CoV should be further evaluated.

Keywords: Healthcare facilities; Healthcare workers; MERS-CoV; Middle East respiratory syndrome; Transmission.

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[1] Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012;367:1814–20. doi: 10.1056/NEJMoa1211721. - DOI - PubMed

[2] Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012;367:1814–20. doi: 10.1056/NEJMoa1211721. - DOI - PubMed

[3] Breakwell L, Pringle K, Chea N, Allen D, Allen S, Richards S, et al. Lack of transmission among close contacts of patient with case of middle east respiratory syndrome imported into the United States, 2014. Emerg Infect Dis. 2015;21(7):1128–34. doi: 10.3201/eid2107.150054. - DOI - PMC - PubMed

[4] Breakwell L, Pringle K, Chea N, Allen D, Allen S, Richards S, et al. Lack of transmission among close contacts of patient with case of middle east respiratory syndrome imported into the United States, 2014. Emerg Infect Dis. 2015;21(7):1128–34. doi: 10.3201/eid2107.150054. - DOI - PMC - PubMed

[5] Assiri A, McGeer A, Perl TM, Price CS, Al Rabeeah AA, Cummings DA, et al. Hospital outbreak of Middle East respiratory syndrome coronavirus. N Engl J Med. 2013;369(5):407–16. doi: 10.1056/NEJMoa1306742. - DOI - PMC - PubMed

[6] Assiri A, McGeer A, Perl TM, Price CS, Al Rabeeah AA, Cummings DA, et al. Hospital outbreak of Middle East respiratory syndrome coronavirus. N Engl J Med. 2013;369(5):407–16. doi: 10.1056/NEJMoa1306742. - DOI - PMC - PubMed

[7] Memish ZA, Zumla AI, Assiri A. Middle East respiratory syndrome coronavirus infections in health care workers. N Engl J Med. 2013;369(9):884–6. doi: 10.1056/NEJMc1308698. - DOI - PubMed

[8] Memish ZA, Zumla AI, Assiri A. Middle East respiratory syndrome coronavirus infections in health care workers. N Engl J Med. 2013;369(9):884–6. doi: 10.1056/NEJMc1308698. - DOI - PubMed

[9] Al-Abdallat MM, Payne DC, Alqasrawi S, Rha B, Tohme RA, Abedi GR, et al. Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description. Clin Infect Dis. 2014;59(9):1225–33. doi: 10.1093/cid/ciu359. - DOI - PMC - PubMed

[10] Al-Abdallat MM, Payne DC, Alqasrawi S, Rha B, Tohme RA, Abedi GR, et al. Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description. Clin Infect Dis. 2014;59(9):1225–33. doi: 10.1093/cid/ciu359. - DOI - PMC - PubMed

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Lack of transmission among healthcare workers in contact with a case of Middle East respiratory syndrome coronavirus infection in Thailand

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Lack of transmission among healthcare workers in contact with a case of Middle East respiratory syndrome coronavirus infection in Thailand

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