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Review
. 2016 May 17;44(5):1069-78.
doi: 10.1016/j.immuni.2016.04.023.

Targeting T Cell Co-receptors for Cancer Therapy

Margaret K Callahan  1 , Michael A Postow  2 , Jedd D Wolchok  3
Affiliations
Free article
Review

Targeting T Cell Co-receptors for Cancer Therapy

Margaret K Callahan et al. Immunity. .
Free article

Abstract

Checkpoint-blocking antibodies can generate potent anti-tumor responses by encouraging the immune system to seek and destroy cancer cells. At this time, the United States Food and Drug Administration has approved three checkpoint-blocking antibodies in three disease indications, and additional approvals are expected to broaden the clinical scope of immunotherapy. Herein, we review the clinical development of CTLA-4-, PD-1-, and PD-L1-blocking antibodies across tumor types and briefly discuss areas of active investigation of potential biomarkers.

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