Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling

doi:10.1155/2016/8419104

Review

. 2016:2016:8419104.

doi: 10.1155/2016/8419104. Epub 2016 Apr 13.

Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling

Luca Genovese¹, Andrea Brendolan¹

Affiliations

PMID: 27190524
PMCID: PMC4846763
DOI: 10.1155/2016/8419104

Review

Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling

Luca Genovese et al. Stem Cells Int. 2016.

. 2016:2016:8419104.

doi: 10.1155/2016/8419104. Epub 2016 Apr 13.

Authors

Luca Genovese¹, Andrea Brendolan¹

Affiliation

¹ Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

PMID: 27190524
PMCID: PMC4846763
DOI: 10.1155/2016/8419104

Abstract

Secondary lymphoid organs (SLOs) are sites that facilitate cell-cell interactions required for generating adaptive immune responses. Nonhematopoietic mesenchymal stromal cells have been shown to play a critical role in SLO function, organization, and tissue homeostasis. The stromal microenvironment undergoes profound remodeling to support immune responses. However, chronic inflammatory conditions can promote uncontrolled stromal cell activation and aberrant tissue remodeling including fibrosis, thus leading to tissue damage. Despite recent advancements, the origin and role of mesenchymal stromal cells involved in SLO development and remodeling remain unclear.

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References

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1. Brendolan A., Rosado M. M., Carsetti R., Selleri L., Dear T. N. Development and function of the mammalian spleen. BioEssays. 2007;29(2):166–177. doi: 10.1002/bies.20528. - DOI - PubMed
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[1] Mueller S. N., Germain R. N. Stromal cell contributions to the homeostasis and functionality of the immune system. Nature Reviews Immunology. 2009;9(9):618–629. doi: 10.1038/nri2588. - DOI - PMC - PubMed

[2] Mueller S. N., Germain R. N. Stromal cell contributions to the homeostasis and functionality of the immune system. Nature Reviews Immunology. 2009;9(9):618–629. doi: 10.1038/nri2588. - DOI - PMC - PubMed

[3] Brendolan A., Rosado M. M., Carsetti R., Selleri L., Dear T. N. Development and function of the mammalian spleen. BioEssays. 2007;29(2):166–177. doi: 10.1002/bies.20528. - DOI - PubMed

[4] Brendolan A., Rosado M. M., Carsetti R., Selleri L., Dear T. N. Development and function of the mammalian spleen. BioEssays. 2007;29(2):166–177. doi: 10.1002/bies.20528. - DOI - PubMed

[5] Brendolan A., Caamaño J. H. Mesenchymal cell differentiation during lymph node organogenesis. Frontiers in Immunology. 2012;3, article 381 doi: 10.3389/fimmu.2012.00381. - DOI - PMC - PubMed

[6] Brendolan A., Caamaño J. H. Mesenchymal cell differentiation during lymph node organogenesis. Frontiers in Immunology. 2012;3, article 381 doi: 10.3389/fimmu.2012.00381. - DOI - PMC - PubMed

[7] Mebius R. E. Organogenesis of lymphoid tissues. Nature Reviews Immunology. 2003;3(4):292–303. doi: 10.1038/nri1054. - DOI - PubMed

[8] Mebius R. E. Organogenesis of lymphoid tissues. Nature Reviews Immunology. 2003;3(4):292–303. doi: 10.1038/nri1054. - DOI - PubMed

[9] Bénézech C., White A., Mader E., et al. Ontogeny of stromal organizer cells during lymph node development. Journal of Immunology. 2010;184(8):4521–4530. doi: 10.4049/jimmunol.0903113. - DOI - PMC - PubMed

[10] Bénézech C., White A., Mader E., et al. Ontogeny of stromal organizer cells during lymph node development. Journal of Immunology. 2010;184(8):4521–4530. doi: 10.4049/jimmunol.0903113. - DOI - PMC - PubMed

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Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling

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Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling

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