Use of tricyclic antidepressants and risk of glioma: a nationwide case-control study

doi:10.1038/bjc.2016.109

Comparative Study

. 2016 May 24;114(11):1265-8.

doi: 10.1038/bjc.2016.109. Epub 2016 Apr 26.

Use of tricyclic antidepressants and risk of glioma: a nationwide case-control study

Anton Pottegård¹, Luis Alberto García Rodríguez², Lotte Rasmussen¹, Per Damkier^{1

3}, Søren Friis⁴, David Gaist^{5

6}

Affiliations

¹ Clinical Pharmacology, Department of Public Health, University of Southern Denmark, Odense, Denmark.
² Centro Español Investigatión Farmacoepidemiológica (CEIFE), Madrid, Spain.
³ Department of Clinical Chemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
⁴ Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.
⁵ Department of Neurology, Odense University Hospital, Odense, Denmark.
⁶ Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.

PMID: 27115466
PMCID: PMC4891498
DOI: 10.1038/bjc.2016.109

Comparative Study

Use of tricyclic antidepressants and risk of glioma: a nationwide case-control study

Anton Pottegård et al. Br J Cancer. 2016.

. 2016 May 24;114(11):1265-8.

doi: 10.1038/bjc.2016.109. Epub 2016 Apr 26.

Authors

Anton Pottegård¹, Luis Alberto García Rodríguez², Lotte Rasmussen¹, Per Damkier^{1

3}, Søren Friis⁴, David Gaist^{5

6}

Affiliations

¹ Clinical Pharmacology, Department of Public Health, University of Southern Denmark, Odense, Denmark.
² Centro Español Investigatión Farmacoepidemiológica (CEIFE), Madrid, Spain.
³ Department of Clinical Chemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
⁴ Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.
⁵ Department of Neurology, Odense University Hospital, Odense, Denmark.
⁶ Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.

PMID: 27115466
PMCID: PMC4891498
DOI: 10.1038/bjc.2016.109

Abstract

Background: A protective effect of tricyclic antidepressants (TCAs) against gliomas has been suggested by a small number of studies. We investigated this putative association in a nationwide setting.

Methods: Using a case-control design, we identified all patients with histologically verified glioma (cases) in Denmark between 2000 and 2012 and matched these 1 : 20 to population controls. Conditional logistic regression was used to estimate adjusted odds ratios (ORs) for glioma associated with long-term (⩾3 years) use of TCAs. Similar analyses were performed for selective serotonin reuptake inhibitors (SSRIs).

Results: We identified 3767 glioma cases and 75 340 population controls. Long-term use of TCAs was inversely associated with risk of glioma (OR 0.72, 95% CI: 0.41-1.25). Long-term SSRI use was not associated with glioma risk (OR 0.93, 95% CI: 0.75-1.16).

Conclusions: Our study indicated that long-term use of TCAs may be associated with a reduced risk of glioma, however, the statistical precision was limited. A similar pattern was not observed for use of SSRIs.

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References

1. Baadsgaard M, Quitzau J (2011) Danish registers on personal income and transfer payments. Scand J Public Health 39: 103–105. - PubMed
1. Chen C, Xu T, Chen J, Zhou J, Yan Y, Lu Y, Wu S (2011) Allergy and risk of glioma: a meta-analysis. Eur J Neurol Off J Eur Fed Neurol Soc 18: 387–395. - PubMed
1. Ferris JS, McCoy L, Neugut AI, Wrensch M, Lai R (2012) HMG CoA reductase inhibitors, NSAIDs and risk of glioma. Int J Cancer J Int Cancer 131: E1031–E1037. - PMC - PubMed
1. Gaist D, Andersen L, Hallas J, Sørensen HT, Schrøder HD, Friis S (2013. a) Use of statins and risk of glioma: a nationwide case-control study in Denmark. Br J Cancer 108: 715–720. - PMC - PubMed
1. Gaist D, García-Rodríguez LA, Sørensen HT, Hallas J, Friis S (2013. b) Use of low-dose aspirin and non-aspirin nonsteroidal anti-inflammatory drugs and risk of glioma: a case-control study. Br J Cancer 108: 1189–1194. - PMC - PubMed

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[1] Baadsgaard M, Quitzau J (2011) Danish registers on personal income and transfer payments. Scand J Public Health 39: 103–105. - PubMed

[2] Baadsgaard M, Quitzau J (2011) Danish registers on personal income and transfer payments. Scand J Public Health 39: 103–105. - PubMed

[3] Chen C, Xu T, Chen J, Zhou J, Yan Y, Lu Y, Wu S (2011) Allergy and risk of glioma: a meta-analysis. Eur J Neurol Off J Eur Fed Neurol Soc 18: 387–395. - PubMed

[4] Chen C, Xu T, Chen J, Zhou J, Yan Y, Lu Y, Wu S (2011) Allergy and risk of glioma: a meta-analysis. Eur J Neurol Off J Eur Fed Neurol Soc 18: 387–395. - PubMed

[5] Ferris JS, McCoy L, Neugut AI, Wrensch M, Lai R (2012) HMG CoA reductase inhibitors, NSAIDs and risk of glioma. Int J Cancer J Int Cancer 131: E1031–E1037. - PMC - PubMed

[6] Ferris JS, McCoy L, Neugut AI, Wrensch M, Lai R (2012) HMG CoA reductase inhibitors, NSAIDs and risk of glioma. Int J Cancer J Int Cancer 131: E1031–E1037. - PMC - PubMed

[7] Gaist D, Andersen L, Hallas J, Sørensen HT, Schrøder HD, Friis S (2013. a) Use of statins and risk of glioma: a nationwide case-control study in Denmark. Br J Cancer 108: 715–720. - PMC - PubMed

[8] Gaist D, Andersen L, Hallas J, Sørensen HT, Schrøder HD, Friis S (2013. a) Use of statins and risk of glioma: a nationwide case-control study in Denmark. Br J Cancer 108: 715–720. - PMC - PubMed

[9] Gaist D, García-Rodríguez LA, Sørensen HT, Hallas J, Friis S (2013. b) Use of low-dose aspirin and non-aspirin nonsteroidal anti-inflammatory drugs and risk of glioma: a case-control study. Br J Cancer 108: 1189–1194. - PMC - PubMed

[10] Gaist D, García-Rodríguez LA, Sørensen HT, Hallas J, Friis S (2013. b) Use of low-dose aspirin and non-aspirin nonsteroidal anti-inflammatory drugs and risk of glioma: a case-control study. Br J Cancer 108: 1189–1194. - PMC - PubMed

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Use of tricyclic antidepressants and risk of glioma: a nationwide case-control study

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Use of tricyclic antidepressants and risk of glioma: a nationwide case-control study

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