Review
doi: 10.1111/odi.12390.
HIV-TB co-infection: mechanisms that drive reactivation of Mycobacterium tuberculosis in HIV infection
Affiliations
- PMID: 27109273
- DOI: 10.1111/odi.12390
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Review
HIV-TB co-infection: mechanisms that drive reactivation of Mycobacterium tuberculosis in HIV infection
Oral Dis.
2016 Apr.
Abstract
HIV infection predisposes the host to tuberculosis by impairing the hosts' immune system principally by killing and altering CD4 T-cell function. How HIV infection disrupts CD4 T-cell function, which specifically compromises host immunity to Mycobacterium tuberculosis, is poorly understood and is a critical roadblock in developing better vaccine- or immune-based strategies to control and monitor TB in HIV-infected subjects. This review considers key pathways that are altered in HIV-infected subjects that impair anti-TB immunity.
Keywords: CD4 T cell; HIV; Interferon; Tuberculosis; reactivation.
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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