Circulating MKRN3 Levels Decline During Puberty in Healthy Boys
- PMID: 27057785
- DOI: 10.1210/jc.2016-1488
Circulating MKRN3 Levels Decline During Puberty in Healthy Boys
Abstract
Context: Initiation and progression of puberty requires concerted action of hypothalamic activating and inhibiting factors. Recently, cases of familial central precocious puberty have been linked to loss-of-function mutations of makorin RING-finger protein 3 (MKRN3) indicating a pivotal inhibitory role of the protein on GnRH secretion.
Objective: To investigate peripubertal circulating MKRN3 levels in healthy boys.
Design: Population-based longitudinal study in healthy Danish boys.
Setting: General community.
Patients or other participants: Healthy boys (n = 60) aged (median [range]) 9.3 (5.8-11.8) years at baseline followed for 6.0 (0.5-7.6) years (2006-2014) with blood sampling every 6 months.
Intervention: None.
Main outcome measures: Serum levels of MKRN3: 623 samples, median (range) 12 (2-14) per boy.
Results: MKRN3 levels declined before onset of puberty; the geometric mean (95% confidence interval) 5 years before onset of puberty vs last visit before onset of puberty was 216 (169-272) pg/mL vs 128 (118-139) pg/mL (P < .001), respectively. MKRN3 levels continued to decrease as puberty progressed. MKRN3 levels were not associated with age at onset of puberty.
Conclusion: Declining MKRN3 before pubertal onset support MKRN3 as an inhibitor of GnRH secretion during midchildhood.
Similar articles
-
Circulating MKRN3 levels decline prior to pubertal onset and through puberty: a longitudinal study of healthy girls.J Clin Endocrinol Metab. 2015 May;100(5):1920-6. doi: 10.1210/jc.2014-4462. Epub 2015 Feb 19. J Clin Endocrinol Metab. 2015. PMID: 25695892
-
Circulating makorin ring finger protein 3 levels decline in boys before the clinical onset of puberty.Eur J Endocrinol. 2016 Jun;174(6):785-90. doi: 10.1530/EJE-15-1193. Epub 2016 Mar 29. Eur J Endocrinol. 2016. PMID: 27025240 Clinical Trial.
-
MKRN3 Levels in Girls with Central Precocious Puberty during GnRHa Treatment: A Longitudinal Study.Horm Res Paediatr. 2018;90(3):190-195. doi: 10.1159/000493134. Epub 2018 Sep 28. Horm Res Paediatr. 2018. PMID: 30269125
-
The Key Roles of Makorin RING Finger Protein 3 (MKRN3) During the Development of Pubertal Initiation and Central Precocious Puberty (CPP).Curr Mol Med. 2023 May 30;23(7):668-677. doi: 10.2174/1566524022666220624105430. Curr Mol Med. 2023. PMID: 35748557 Review.
-
A new pathway in the control of the initiation of puberty: the MKRN3 gene.J Mol Endocrinol. 2015 Jun;54(3):R131-9. doi: 10.1530/JME-14-0315. J Mol Endocrinol. 2015. PMID: 25957321 Free PMC article. Review.
Cited by
-
Genetics of pubertal timing.Best Pract Res Clin Endocrinol Metab. 2022 Jan;36(1):101618. doi: 10.1016/j.beem.2022.101618. Epub 2022 Feb 5. Best Pract Res Clin Endocrinol Metab. 2022. PMID: 35183440 Free PMC article. Review.
-
Six Novel Variants in the MKRN3 Gene Causing Central Precocious Puberty.J Endocr Soc. 2022 Nov 4;7(1):bvac168. doi: 10.1210/jendso/bvac168. eCollection 2022 Nov 17. J Endocr Soc. 2022. PMID: 36438546 Free PMC article.
-
Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3.PLoS Biol. 2019 Nov 7;17(11):e3000532. doi: 10.1371/journal.pbio.3000532. eCollection 2019 Nov. PLoS Biol. 2019. PMID: 31697675 Free PMC article.
-
Minipuberty of human infancy - A window of opportunity to evaluate hypogonadism and differences of sex development?Ann Pediatr Endocrinol Metab. 2020 Jun;25(2):84-91. doi: 10.6065/apem.2040094.047. Epub 2020 Jun 30. Ann Pediatr Endocrinol Metab. 2020. PMID: 32615687 Free PMC article.
-
Central precocious puberty: Recent advances in understanding the aetiology and in the clinical approach.Clin Endocrinol (Oxf). 2021 Oct;95(4):542-555. doi: 10.1111/cen.14475. Epub 2021 Apr 20. Clin Endocrinol (Oxf). 2021. PMID: 33797780 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
