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. 2016 Apr 7;22(13):3611-20.
doi: 10.3748/wjg.v22.i13.3611.

Different risk factors for advanced colorectal neoplasm in young adults

Ji Yeon Kim  1 , Yoon Suk Jung  1 , Jung Ho Park  1 , Hong Joo Kim  1 , Yong Kyun Cho  1 , Chong Il Sohn  1 , Woo Kyu Jeon  1 , Byung Ik Kim  1 , Kyu Yong Choi  1 , Dong Il Park  1
Affiliations

Different risk factors for advanced colorectal neoplasm in young adults

Ji Yeon Kim et al. World J Gastroenterol. .

Abstract

Aim: To compare the risk of developing advanced colorectal neoplasm (ACRN) according to age in Koreans.

Methods: A total of 70428 Koreans from an occupational cohort who underwent a colonoscopy between 2003 and 2012 at Kangbuk Samsung Hospital were retrospectively selected. We evaluated and compared odds ratios (OR) for ACRN between the young-adults (YA < 50 years) and in the older-adults (OA ≥ 50 years). ACRN was defined as an adenoma ≥ 10 mm in diameter, adenoma with any component of villous histology, high-grade dysplasia, or invasive cancer.

Results: In the YA group, age (OR = 1.08, 95%CI: 1.06-1.09), male sex (OR = 1.26, 95%CI: 1.02-1.55), current smoking (OR = 1.37, 95%CI: 1.15-1.63), family history of colorectal cancer (OR = 1.46, 95%CI: 1.01-2.10), diabetes mellitus related factors (OR = 1.27, 95%CI: 1.06-1.54), obesity (OR = 1.23, 95%CI: 1.03-1.47), CEA (OR = 1.04, 95%CI: 1.01-1.09) and low-density lipoprotein-cholesterol (OR = 1.01, 95%CI: 1.01-1.02) were related with an increased risk of ACRN. However, age (OR = 1.08, 95%CI: 1.06-1.09), male sex (OR = 2.12, 95%CI: 1.68-2.68), current smoking (OR = 1.38, 95%CI: 1.12-1.71), obesity (OR = 1.34, 95%CI: 1.09-1.65) and CEA (OR = 1.05, 95%CI: 1.01-1.09) also increased the risk of ACRN in the OA group.

Conclusion: The risks of ACRN differed based on age group. Different colonoscopic screening strategies are appropriate for particular subjects with risk factors for ACRN, even in subjects younger than 50 years.

Keywords: Advanced colorectal neoplasm; Age; Metabolic abnormality; Risk factors; Young-adult.

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Figure 1
Flow diagram of subject enrollment.
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