Amyloid-β and Astrocytes Interplay in Amyloid-β Related Disorders

doi:10.3390/ijms17030338

Review

. 2016 Mar 4;17(3):338.

doi: 10.3390/ijms17030338.

Amyloid-β and Astrocytes Interplay in Amyloid-β Related Disorders

Yazan S Batarseh¹, Quoc-Viet Duong², Youssef M Mousa³, Sweilem B Al Rihani⁴, Khaled Elfakhri⁵, Amal Kaddoumi⁶

Affiliations

¹ Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA. batarsy@warhawks.ulm.edu.
² Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA. duongqa@warhawks.ulm.edu.
³ Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA. mousaym@warhawks.ulm.edu.
⁴ Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA. alrihasb@warhawks.ulm.edu.
⁵ Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA. hamadgh@warhawks.ulm.edu.
⁶ Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA. kaddoumi@ulm.edu.

PMID: 26959008
PMCID: PMC4813200
DOI: 10.3390/ijms17030338

Review

Amyloid-β and Astrocytes Interplay in Amyloid-β Related Disorders

Yazan S Batarseh et al. Int J Mol Sci. 2016.

. 2016 Mar 4;17(3):338.

doi: 10.3390/ijms17030338.

Authors

Yazan S Batarseh¹, Quoc-Viet Duong², Youssef M Mousa³, Sweilem B Al Rihani⁴, Khaled Elfakhri⁵, Amal Kaddoumi⁶

Affiliations

¹ Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA. batarsy@warhawks.ulm.edu.
² Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA. duongqa@warhawks.ulm.edu.
³ Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA. mousaym@warhawks.ulm.edu.
⁴ Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA. alrihasb@warhawks.ulm.edu.
⁵ Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA. hamadgh@warhawks.ulm.edu.
⁶ Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA. kaddoumi@ulm.edu.

PMID: 26959008
PMCID: PMC4813200
DOI: 10.3390/ijms17030338

Abstract

Amyloid-β (Aβ) pathology is known to promote chronic inflammatory responses in the brain. It was thought previously that Aβ is only associated with Alzheimer's disease and Down syndrome. However, studies have shown its involvement in many other neurological disorders. The role of astrocytes in handling the excess levels of Aβ has been highlighted in the literature. Astrocytes have a distinctive function in both neuronal support and protection, thus its involvement in Aβ pathological process may tip the balance toward chronic inflammation and neuronal death. In this review we describe the involvement of astrocytes in Aβ related disorders including Alzheimer's disease, Down syndrome, cerebral amyloid angiopathy, and frontotemporal dementia.

Keywords: Alzheimer’s disease; Amyloid-β; Down syndrome; astrocytes; cerebral amyloid angiopathy; frontotemporal dementia.

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References

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1. Masters C.L., Simms G., Weinman N.A., Multhaup G., McDonald B.L., Beyreuther K. Amyloid plaque core protein in Alzheimer disease and down syndrome. Proc. Natl. Acad. Sci. USA. 1985;82:4245–4249. doi: 10.1073/pnas.82.12.4245. - DOI - PMC - PubMed
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1. Kacem K., Lacombe P., Seylaz J., Bonvento G. Structural organization of the perivascular astrocyte endfeet and their relationship with the endothelial glucose transporter: A confocal microscopy study. Glia. 1998;23:1–10. doi: 10.1002/(SICI)1098-1136(199805)23:1<1::AID-GLIA1>3.0.CO;2-B. - DOI - PubMed
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[1] Glenner G.G., Wong C.W. Alzheimer’s disease and down’s syndrome: Sharing of a unique cerebrovascular amyloid fibril protein. Biochem. Biophys. Res. Commun. 1984;122:1131–1135. doi: 10.1016/0006-291X(84)91209-9. - DOI - PubMed

[2] Glenner G.G., Wong C.W. Alzheimer’s disease and down’s syndrome: Sharing of a unique cerebrovascular amyloid fibril protein. Biochem. Biophys. Res. Commun. 1984;122:1131–1135. doi: 10.1016/0006-291X(84)91209-9. - DOI - PubMed

[3] Masters C.L., Simms G., Weinman N.A., Multhaup G., McDonald B.L., Beyreuther K. Amyloid plaque core protein in Alzheimer disease and down syndrome. Proc. Natl. Acad. Sci. USA. 1985;82:4245–4249. doi: 10.1073/pnas.82.12.4245. - DOI - PMC - PubMed

[4] Masters C.L., Simms G., Weinman N.A., Multhaup G., McDonald B.L., Beyreuther K. Amyloid plaque core protein in Alzheimer disease and down syndrome. Proc. Natl. Acad. Sci. USA. 1985;82:4245–4249. doi: 10.1073/pnas.82.12.4245. - DOI - PMC - PubMed

[5] Selkoe D.J. Alzheimer’s disease: Genes, proteins, and therapy. Physiol. Rev. 2001;81:741–766. doi: 10.1101/cshperspect.a004457. - DOI - PubMed

[6] Selkoe D.J. Alzheimer’s disease: Genes, proteins, and therapy. Physiol. Rev. 2001;81:741–766. doi: 10.1101/cshperspect.a004457. - DOI - PubMed

[7] Kacem K., Lacombe P., Seylaz J., Bonvento G. Structural organization of the perivascular astrocyte endfeet and their relationship with the endothelial glucose transporter: A confocal microscopy study. Glia. 1998;23:1–10. doi: 10.1002/(SICI)1098-1136(199805)23:1<1::AID-GLIA1>3.0.CO;2-B. - DOI - PubMed

[8] Kacem K., Lacombe P., Seylaz J., Bonvento G. Structural organization of the perivascular astrocyte endfeet and their relationship with the endothelial glucose transporter: A confocal microscopy study. Glia. 1998;23:1–10. doi: 10.1002/(SICI)1098-1136(199805)23:1<1::AID-GLIA1>3.0.CO;2-B. - DOI - PubMed

[9] Abbott N.J. Astrocyte-endothelial interactions and blood-brain barrier permeability. J. Anat. 2002;200:629–638. doi: 10.1046/j.1469-7580.2002.00064.x. - DOI - PMC - PubMed

[10] Abbott N.J. Astrocyte-endothelial interactions and blood-brain barrier permeability. J. Anat. 2002;200:629–638. doi: 10.1046/j.1469-7580.2002.00064.x. - DOI - PMC - PubMed

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Amyloid-β and Astrocytes Interplay in Amyloid-β Related Disorders

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Amyloid-β and Astrocytes Interplay in Amyloid-β Related Disorders

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