Meta-analysis of cellular toxicity for cadmium-containing quantum dots

doi:10.1038/nnano.2015.338

Meta-Analysis

. 2016 May;11(5):479-86.

doi: 10.1038/nnano.2015.338. Epub 2016 Feb 29.

Meta-analysis of cellular toxicity for cadmium-containing quantum dots

Eunkeu Oh^{1

2}, Rong Liu^{3

4}, Andre Nel^{4

5}, Kelly Boeneman Gemill⁶, Muhammad Bilal⁴, Yoram Cohen^{3

4

7}, Igor L Medintz⁶

Affiliations

¹ Optical Sciences Division, Code 5611, US Naval Research Laboratory, Washington, Washington DC 20375, USA.
² Sotera Defense Solutions, Columbia, Maryland 21046, USA.
³ Institute of the Environment and Sustainability, University of California, Los Angeles, California 90095-1496, USA.
⁴ Center for Environmental Implications of Nanotechnology, University of California, Los Angeles, California 90095-7227, USA.
⁵ Department of Medicine, Division of NanoMedicine, University of California, Los Angeles, California 90095, USA.
⁶ Center for Bio/Molecular Science and Engineering, Code 6900, US Naval Research Laboratory, SW Washington, Washington DC 20375, USA.
⁷ Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095-1592, USA.

PMID: 26925827
DOI: 10.1038/nnano.2015.338

Meta-Analysis

Meta-analysis of cellular toxicity for cadmium-containing quantum dots

Eunkeu Oh et al. Nat Nanotechnol. 2016 May.

. 2016 May;11(5):479-86.

doi: 10.1038/nnano.2015.338. Epub 2016 Feb 29.

Authors

Eunkeu Oh^{1

2}, Rong Liu^{3

4}, Andre Nel^{4

5}, Kelly Boeneman Gemill⁶, Muhammad Bilal⁴, Yoram Cohen^{3

4

7}, Igor L Medintz⁶

Affiliations

¹ Optical Sciences Division, Code 5611, US Naval Research Laboratory, Washington, Washington DC 20375, USA.
² Sotera Defense Solutions, Columbia, Maryland 21046, USA.
³ Institute of the Environment and Sustainability, University of California, Los Angeles, California 90095-1496, USA.
⁴ Center for Environmental Implications of Nanotechnology, University of California, Los Angeles, California 90095-7227, USA.
⁵ Department of Medicine, Division of NanoMedicine, University of California, Los Angeles, California 90095, USA.
⁶ Center for Bio/Molecular Science and Engineering, Code 6900, US Naval Research Laboratory, SW Washington, Washington DC 20375, USA.
⁷ Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095-1592, USA.

PMID: 26925827
DOI: 10.1038/nnano.2015.338

Abstract

Understanding the relationships between the physicochemical properties of engineered nanomaterials and their toxicity is critical for environmental and health risk analysis. However, this task is confounded by material diversity, heterogeneity of published data and limited sampling within individual studies. Here, we present an approach for analysing and extracting pertinent knowledge from published studies focusing on the cellular toxicity of cadmium-containing semiconductor quantum dots. From 307 publications, we obtain 1,741 cell viability-related data samples, each with 24 qualitative and quantitative attributes describing the material properties and experimental conditions. Using random forest regression models to analyse the data, we show that toxicity is closely correlated with quantum dot surface properties (including shell, ligand and surface modifications), diameter, assay type and exposure time. Our approach of integrating quantitative and categorical data provides a roadmap for interrogating the wide-ranging toxicity data in the literature and suggests that meta-analysis can help develop methods for predicting the toxicity of engineered nanomaterials.

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Comment in

Nanotoxicology: Seeing the trees for the forest.
Casman EA, Gernand JM. Casman EA, et al. Nat Nanotechnol. 2016 May;11(5):405-7. doi: 10.1038/nnano.2016.5. Epub 2016 Feb 29. Nat Nanotechnol. 2016. PMID: 26925825 No abstract available.

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[1] Analyst. 2012 Nov 7;137(21):5123-7 - PubMed

[2] Analyst. 2012 Nov 7;137(21):5123-7 - PubMed

[3] J Mater Sci Mater Med. 2009 Sep;20(9):1945-53 - PubMed

[4] J Mater Sci Mater Med. 2009 Sep;20(9):1945-53 - PubMed

[5] ACS Nano. 2013 Oct 22;7(10):8397-411 - PubMed

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[9] Biomaterials. 2011 May;32(13):3520-37 - PubMed

[10] Biomaterials. 2011 May;32(13):3520-37 - PubMed

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Meta-analysis of cellular toxicity for cadmium-containing quantum dots

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